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The Body Mass Index Paradox in Head and Neck Cancer: A Systematic Review and Meta-Analysis.
Hobday, Sara; Armache, Maria; Paquin, Rebecca; Nurimba, Margaret; Baddour, Khalil; Linder, Daniel; Kouame, Gail; Tharrington, Shafer; Albergotti, William G; Mady, Leila J.
Afiliación
  • Hobday S; Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA, USA.
  • Armache M; Department of Otolaryngology-Head & Neck Surgery, Thomas Jefferson University, Philadelphia, PA, USA.
  • Paquin R; Department of Otolaryngology-Head and Neck Surgery, Augusta University, Augusta, GA, USA.
  • Nurimba M; Department of Otolaryngology-Head and Neck Surgery, University of Southern California, Los Angeles, CA, USA.
  • Baddour K; Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
  • Linder D; Division of Biostatistics and Data Science, Medical College of Georgia, Augusta University, Augusta, GA, USA.
  • Kouame G; Greenblatt Library, Augusta University, Augusta, GA, USA.
  • Tharrington S; Greenblatt Library, Augusta University, Augusta, GA, USA.
  • Albergotti WG; Department of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, USA.
  • Mady LJ; Department of Otolaryngology-Head & Neck Surgery, Thomas Jefferson University, Philadelphia, PA, USA.
Nutr Cancer ; 75(1): 48-60, 2023.
Article en En | MEDLINE | ID: mdl-35959747
ABSTRACT
The body mass index (BMI) paradox describes that among patients with certain cancers, higher pretreatment BMI may be associated with improved survival. We examine the impact of BMI on overall survival (OS) in head and neck squamous cell carcinoma (HNSCC) patients. A literature search was performed, and articles using hazard ratios to describe the prognostic impact of BMI on OS in HNSCC were included. Random-effects DerSimonian and Laird methods were employed for meta-analysis. Meta-analysis of OS indicated a lower hazards of death in the overweight (BMI 25 kg/m2-30 kg/m2) compared to the normal weight (BMI 18.5 kg/m2-25 kg/m2). This protective relationship loses significance when BMI exceeds 30 kg/m2. Underweight patients (BMI < 18.5 kg/m2) demonstrate higher hazards of death compared to normal weight patients. Compared to HNSCC patients with normal weight, being overweight up to a BMI of 30 kg/m2 is a positive predictor of OS, while being underweight confers a prognostic disadvantage. Further studies are needed to determine the mechanisms by which increased body mass influences survival outcomes in HNSCC.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Paradoja de la Obesidad / Neoplasias de Cabeza y Cuello Tipo de estudio: Prognostic_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Nutr Cancer Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Paradoja de la Obesidad / Neoplasias de Cabeza y Cuello Tipo de estudio: Prognostic_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Nutr Cancer Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos