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CD5 Suppresses IL-15-Induced Proliferation of Human Memory CD8+ T Cells by Inhibiting mTOR Pathways.
Choi, Young Joon; Lee, Hoyoung; Kim, Jong Hoon; Kim, So-Young; Koh, June-Young; Sa, Moa; Park, Su-Hyung; Shin, Eui-Cheol.
Afiliación
  • Choi YJ; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
  • Lee H; Department of Ophthalmology, Ajou University School of Medicine, Suwon, Korea.
  • Kim JH; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
  • Kim SY; The Center for Viral Immunology, Korea Virus Research Institute, Institute for Basic Science, Daejeon, Republic of Korea; and.
  • Koh JY; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
  • Sa M; Department of Dermatology, Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Park SH; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
  • Shin EC; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
J Immunol ; 209(6): 1108-1117, 2022 09 15.
Article en En | MEDLINE | ID: mdl-36002232
IL-15 induces the proliferation of memory CD8+ T cells as well as NK cells. The expression of CD5 inversely correlates with the IL-15 responsiveness of human memory CD8+ T cells. However, whether CD5 directly regulates IL-15-induced proliferation of human memory CD8+ T cells is unknown. In the current study, we demonstrate that human memory CD8+ T cells in advanced stages of differentiation respond to IL-15 better than human memory CD8+ T cells in stages of less differentiation. We also found that the expression level of CD5 is the best correlate for IL-15 hyporesponsiveness among human memory CD8+ T cells. Importantly, we found that IL-15-induced proliferation of human memory CD8+ T cells is significantly enhanced by blocking CD5 with Abs or knocking down CD5 expression using small interfering RNA, indicating that CD5 directly suppresses the IL-15-induced proliferation of human memory CD8+ T cells. We also found that CD5 inhibits activation of the mTOR pathway, which is required for IL-15-induced proliferation of human memory CD8+ T cells. Taken together, the results indicate that CD5 is not just a correlative marker for IL-15 hyporesponsiveness, but it also directly suppresses IL-15-induced proliferation of human memory CD8+ T cells by inhibiting mTOR pathways.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Linfocitos T CD8-positivos / Antígenos CD5 / Interleucina-15 / Serina-Treonina Quinasas TOR Límite: Humans Idioma: En Revista: J Immunol Año: 2022 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Linfocitos T CD8-positivos / Antígenos CD5 / Interleucina-15 / Serina-Treonina Quinasas TOR Límite: Humans Idioma: En Revista: J Immunol Año: 2022 Tipo del documento: Article