Cytochromes P450 2C8 and 3A Catalyze the Metabolic Activation of the Tyrosine Kinase Inhibitor Masitinib.

Latham, Bethany D; Oskin, D Spencer; Crouch, Rachel D; Vergne, Matthew J; Jackson, Klarissa D

Latham, Bethany D; Oskin, D Spencer; Crouch, Rachel D; Vergne, Matthew J; Jackson, Klarissa D.

Afiliación

Latham BD; Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina at Chapel Hill Eshelman School of Pharmacy, Chapel Hill, North Carolina 27599, United States.
Oskin DS; Department of Pharmaceutical Sciences, Lipscomb University College of Pharmacy and Health Sciences, Nashville, Tennessee 37204, United States.
Crouch RD; Department of Pharmaceutical Sciences, Lipscomb University College of Pharmacy and Health Sciences, Nashville, Tennessee 37204, United States.
Vergne MJ; Department of Pharmaceutical Sciences, Lipscomb University College of Pharmacy and Health Sciences, Nashville, Tennessee 37204, United States.
Jackson KD; Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina at Chapel Hill Eshelman School of Pharmacy, Chapel Hill, North Carolina 27599, United States.

Chem Res Toxicol ; 35(9): 1467-1481, 2022 09 19.

Article en En | MEDLINE | ID: mdl-36048877

Asunto(s)

COVID-19; Activación Metabólica; Benzamidas; Catálisis; Sistema Enzimático del Citocromo P-450/metabolismo; Humanos; Microsomas Hepáticos/metabolismo; NADP/metabolismo; Piperidinas; Cianuro de Potasio; Inhibidores de Proteínas Quinasas/metabolismo; Inhibidores de Proteínas Quinasas/farmacología; Piridinas; Tiazoles

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: COVID-19 Límite: Humans Idioma: En Revista: Chem Res Toxicol Asunto de la revista: TOXICOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

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