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Patient-Derived Organoids from Colorectal Cancer with Paired Liver Metastasis Reveal Tumor Heterogeneity and Predict Response to Chemotherapy.
Mo, Shaobo; Tang, Peiyuan; Luo, Wenqin; Zhang, Long; Li, Yaqi; Hu, Xiang; Ma, Xiaoji; Chen, Yikuan; Bao, Yichao; He, Xingfeng; Fu, Guoxiang; Xu, Xiaoya; Rao, Xinxin; Li, Xiaomeng; Guan, Ruoyu; Chen, Shengzhi; Deng, Yun; Lv, Tao; Mu, Peiyuan; Zheng, Qiang; Wang, Simin; Liu, Fangqi; Li, Yiwei; Sheng, Weiqi; Huang, Dan; Hu, Chen; Gao, Jianjun; Zhang, Zhen; Cai, Sanjun; Clevers, Hans; Peng, Junjie; Hua, Guoqiang.
Afiliación
  • Mo S; Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, P. R. China.
  • Tang P; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, P. R. China.
  • Luo W; Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, 200032, P. R. China.
  • Zhang L; Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, P. R. China.
  • Li Y; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, P. R. China.
  • Hu X; Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, P. R. China.
  • Ma X; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, P. R. China.
  • Chen Y; Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, 200032, P. R. China.
  • Bao Y; Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, P. R. China.
  • He X; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, P. R. China.
  • Fu G; Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, P. R. China.
  • Xu X; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, P. R. China.
  • Rao X; Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, P. R. China.
  • Li X; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, P. R. China.
  • Guan R; Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, P. R. China.
  • Chen S; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, P. R. China.
  • Deng Y; Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, P. R. China.
  • Lv T; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, P. R. China.
  • Mu P; Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, P. R. China.
  • Zheng Q; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, P. R. China.
  • Wang S; Research and Early Development, D1Med Technology (Shanghai) Inc, Shanghai, 200235, P. R. China.
  • Liu F; Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, 200032, P. R. China.
  • Li Y; Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, 200032, P. R. China.
  • Sheng W; Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, 200032, P. R. China.
  • Huang D; Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, 200032, P. R. China.
  • Hu C; Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, 200032, P. R. China.
  • Gao J; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, P. R. China.
  • Zhang Z; Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, 200032, P. R. China.
  • Cai S; Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, P. R. China.
  • Clevers H; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, P. R. China.
  • Peng J; Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, P. R. China.
  • Hua G; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, P. R. China.
Adv Sci (Weinh) ; 9(31): e2204097, 2022 11.
Article en En | MEDLINE | ID: mdl-36058001
ABSTRACT
There is no effective method to predict chemotherapy response and postoperative prognosis of colorectal cancer liver metastasis (CRLM) patients. Patient-derived organoid (PDO) has become an important preclinical model. Herein, a living biobank with 50 CRLM organoids derived from primary tumors and paired liver metastatic lesions is successfully constructed. CRLM PDOs from the multiomics levels (histopathology, genome, transcriptome and single-cell sequencing) are comprehensively analyzed and confirmed that this organoid platform for CRLM could capture intra- and interpatient heterogeneity. The chemosensitivity data in vitro reveal the potential value of clinical application for PDOs to predict chemotherapy response (FOLFOX or FOLFIRI) and clinical prognosis of CRLM patients. Taken together, CRLM PDOs can be utilized to deliver a potential application for personalized medicine.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Neoplasias Hepáticas / Antineoplásicos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Adv Sci (Weinh) Año: 2022 Tipo del documento: Article
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Neoplasias Hepáticas / Antineoplásicos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Adv Sci (Weinh) Año: 2022 Tipo del documento: Article