Your browser doesn't support javascript.
loading
Determination of chlorpromazine and its metabolites in animal-derived foods using QuEChERS-based extraction, EMR-Lipid cleanup, and UHPLC-Q-Orbitrap MS analysis.
Dai, Jinxia; Lin, Hui; Pan, Yuning; Sun, Yanmin; Wang, Ye; Qiao, Jun-Qin; Lian, Hong-Zhen; Xu, Chun-Xiang.
Afiliación
  • Dai J; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry & Chemical Engineering and Center of Materials Analysis, Nanjing University, Nanjing, 210023, China.
  • Lin H; Jiangsu Institute for Food and Drug Control, 6 Beijing West Road, Nanjing 210008, China.
  • Pan Y; Jiangsu Institute for Food and Drug Control, 6 Beijing West Road, Nanjing 210008, China.
  • Sun Y; Jiangsu Institute for Food and Drug Control, 6 Beijing West Road, Nanjing 210008, China.
  • Wang Y; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry & Chemical Engineering and Center of Materials Analysis, Nanjing University, Nanjing, 210023, China.
  • Qiao JQ; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry & Chemical Engineering and Center of Materials Analysis, Nanjing University, Nanjing, 210023, China.
  • Lian HZ; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry & Chemical Engineering and Center of Materials Analysis, Nanjing University, Nanjing, 210023, China. Electronic address: hzlian@nju.edu.cn.
  • Xu CX; Jiangsu Institute for Food and Drug Control, 6 Beijing West Road, Nanjing 210008, China. Electronic address: xcx70@163.com.
Food Chem ; 403: 134298, 2023 Mar 01.
Article en En | MEDLINE | ID: mdl-36182851
ABSTRACT
Chlorpromazine (CPZ) is abused in animal husbandry and can be extensively metabolized in humans and animals. However, the actual monitoring mainly focuses on the parent compound but lacks attention to its metabolites. A method was developed and validated firstly for identification and determination of CPZ and its four major metabolites in animal-derived foods using ultrahigh-performance liquid chromatography coupled with quadrupole-Orbitrap mass spectrometry in combination with QuEChERS preparation method. Satisfactory recoveries of analytes spiked in fish and pork samples ranged from 72 to 117 %, and limits of quantification were 2.0 and 1.0 µg kg-1 for fish and pork samples respectively. Moreover, through the hydrolysis experiments of CPZ, its hydrolysates, such as CPZ-sulfoxide, CPZ-N-oxide and CPZ-sulfoxide-N-oxide, were identified as potential risk compounds. The developed method has been successfully applied to the determination of CPZ and its metabolites in actual commercial samples, as well as to the screening of other CPZ-related risk compounds.
Asunto(s)
Palabras clave

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Clorpromazina / Lípidos Límite: Animals / Humans Idioma: En Revista: Food Chem Año: 2023 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Clorpromazina / Lípidos Límite: Animals / Humans Idioma: En Revista: Food Chem Año: 2023 Tipo del documento: Article País de afiliación: China