One-Pot Sequential Synthesis of 3,3'- or 2,3'-Bis(indolyl)methanes by Using 1,3-Dithiane as the Methylene Source.

Dong, Kang; Li, Jia; Li, Rui-Peng; Mao, Mingming; Liu, Jian; Wang, Xiaolei; Tang, Shouchu

Dong, Kang; Li, Jia; Li, Rui-Peng; Mao, Mingming; Liu, Jian; Wang, Xiaolei; Tang, Shouchu.

Afiliación

Dong K; School of Pharmacy and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China.
Li J; School of Pharmacy and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China.
Li RP; School of Pharmacy and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China.
Mao M; School of Pharmacy and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China.
Liu J; School of Pharmacy and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China.
Wang X; School of Pharmacy and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China.
Tang S; School of Pharmacy and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China.

J Org Chem ; 87(21): 14930-14939, 2022 11 04.

Article en En | MEDLINE | ID: mdl-36259953

ABSTRACT

ABSTRACT

A simple and efficient method for structurally diverse symmetrical and unsymmetrical 3,3'- and 2,3'-bisindolylmethanes has been developed through a one-pot sequential reaction using 1,3-dithiane as the methylene source. The important AhR agonists ICZ and malassezin were synthesized with excellent efficiency by this straightforward approach.

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Metano Idioma: En Revista: J Org Chem Año: 2022 Tipo del documento: Article