Enzymatic synthesis of anhydroicaritin, baohuoside and icariin.
J Asian Nat Prod Res
; 25(7): 667-673, 2023.
Article
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| MEDLINE
| ID: mdl-36272133
ABSTRACT
Anhydroicaritin (1a), baohuoside (1b) and icariin (1c) were recognized as major pharmacologically active ingredients of Epimedium plants. Their primary means of acquisition were chemical isolation from plants. However, it suffers from low yield, environmental pollution and shortage of plants. Herein, to remedy these problems, biosynthesis was explored to obtain the three active ingredients. Fortunately, with SfFPT as 8-prenyltransferase, EpPF3RT and Ep7GT as glycosyltransferases, kaempferide (1) was transferred to 1a, 1b and 1c enzymatically. Thus, we report the details of this method. This approach represents a promising environmental friendly alternative for the production of these compounds from an abundant analogue.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Benzopiranos
/
Flavonoides
Idioma:
En
Revista:
J Asian Nat Prod Res
Asunto de la revista:
BOTANICA
/
QUIMICA
Año:
2023
Tipo del documento:
Article