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Visualizing ligand bias at the Mu-opioid receptor.
Zamorano, Catalina A; Bruchas, Michael R.
Afiliación
  • Zamorano CA; Department of Pharmacology, University of Washington, Seattle, WA 98195, USA; Center for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA 98195, USA.
  • Bruchas MR; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98195, USA; Department of Pharmacology, University of Washington, Seattle, WA 98195, USA; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA; Center for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA 98195, USA. Electronic address: mbruchas@uw.edu.
Cell ; 185(23): 4251-4253, 2022 11 10.
Article en En | MEDLINE | ID: mdl-36368303
Different opioid ligands can result in biased µ-opioid signaling, differentially activating signal cascades which produce analgesia, tolerance, or adverse effects. In this issue of Cell, Xu et al. used cryo-EM and computational simulations to understand how different µ-opioid receptor selective-ligands interact with key residues to produce downstream signaling.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Dolor / Analgésicos Opioides Límite: Humans Idioma: En Revista: Cell Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Dolor / Analgésicos Opioides Límite: Humans Idioma: En Revista: Cell Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos