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Electrospun Mucoadhesive Zein/PVP Fibroporous Membrane for Transepithelial Delivery of Propranolol Hydrochloride.
Surendranath, Medha; Ramesan, Rekha M; Nair, Prakash; Parameswaran, Ramesh.
Afiliación
  • Surendranath M; Division of Polymeric Medical Devices, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram695012, Kerala, India.
  • Ramesan RM; Division of Biosurface Technology, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram695012, Kerala, India.
  • Nair P; Department of Neurosurgery, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram695012, Kerala, India.
  • Parameswaran R; Division of Polymeric Medical Devices, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram695012, Kerala, India.
Mol Pharm ; 20(1): 508-523, 2023 01 02.
Article en En | MEDLINE | ID: mdl-36373686
Mucoadhesive drug delivery systems have been extensively studied to effectively reduce the limitations of conventional drug delivery systems. Zein and polyvinyl pyrrolidone (PVP) are appraised for mucoadhesive properties. This study focuses on developing a mechanically stable zein/PVP electrospun membrane for propranolol hydrochloride (PL) transport. Fourier transform infrared, Raman spectra, and swelling studies gave evidence for PVP crosslinking, whereas circular dichroism spectroscopy revealed crosslinking of zein owing to the conformational change from α-helix to ß-sheet. A 10 h thermal treatment of zein/PVP imparted 3.92 ± 0.13 MPa tensile strength to the matrix. Thermally crosslinked electrospun zein/PVP matrix showed 22.1 ± 0.1 g mm work of adhesion in porcine buccal mucosa tissue. Qualitative and quantitative evaluation of cytotoxicity in RPMI 2650 has been carried out. The in vitro drug release profile of PL from thermally crosslinked zein/PVP best fitted with the Korsmeyer-Peppas model. Immunostaining of ß-catenin adherens junctional protein confirmed the absence of paracellular transport through the junctional opening. Still, drug permeation was observed through the porcine buccal mucosa, attributed to the transcellular transport of PL owing to its lipophilicity. The ex vivo permeation of PL through porcine buccal mucosa was also evaluated.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Propranolol / Zeína Tipo de estudio: Qualitative_research Límite: Animals Idioma: En Revista: Mol Pharm Asunto de la revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: India

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Propranolol / Zeína Tipo de estudio: Qualitative_research Límite: Animals Idioma: En Revista: Mol Pharm Asunto de la revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: India