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Optimization of 1,2,4-Triazole-3-thiones toward Broad-Spectrum Metallo-ß-lactamase Inhibitors Showing Potent Synergistic Activity on VIM- and NDM-1-Producing Clinical Isolates.
Legru, Alice; Verdirosa, Federica; Vo-Hoang, Yen; Tassone, Giusy; Vascon, Filippo; Thomas, Caitlyn A; Sannio, Filomena; Corsica, Giuseppina; Benvenuti, Manuela; Feller, Georges; Coulon, Rémi; Marcoccia, Francesca; Devente, Savannah Rowane; Bouajila, Ezeddine; Piveteau, Catherine; Leroux, Florence; Deprez-Poulain, Rebecca; Deprez, Benoît; Licznar-Fajardo, Patricia; Crowder, Michael W; Cendron, Laura; Pozzi, Cecilia; Mangani, Stefano; Docquier, Jean-Denis; Hernandez, Jean-François; Gavara, Laurent.
Afiliación
  • Legru A; IBMM, CNRS, Univ Montpellier, ENSCM, 34000 Montpellier, France.
  • Verdirosa F; Dipartimento di Biotecnologie Mediche, Università di Siena, 53100 Siena, Italy.
  • Vo-Hoang Y; IBMM, CNRS, Univ Montpellier, ENSCM, 34000 Montpellier, France.
  • Tassone G; Dipartimento di Biotecnologie, Chimica e Farmacia, Università di Siena, 53100 Siena, Italy.
  • Vascon F; Laboratory of Structural Biology, Department of Biology, University of Padua, 35121 Padova, Italy.
  • Thomas CA; Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056, United States.
  • Sannio F; Dipartimento di Biotecnologie Mediche, Università di Siena, 53100 Siena, Italy.
  • Corsica G; Dipartimento di Biotecnologie Mediche, Università di Siena, 53100 Siena, Italy.
  • Benvenuti M; Dipartimento di Biotecnologie, Chimica e Farmacia, Università di Siena, 53100 Siena, Italy.
  • Feller G; Laboratoire de Biochimie, Centre d'Ingénierie des Protéines-InBioS, Université de Liège, Allée du 6 août B6, Sart-Tilman, B-4000 Liège, Belgium.
  • Coulon R; IBMM, CNRS, Univ Montpellier, ENSCM, 34000 Montpellier, France.
  • Marcoccia F; Dipartimento di Biotecnologie Mediche, Università di Siena, 53100 Siena, Italy.
  • Devente SR; Dipartimento di Biotecnologie Mediche, Università di Siena, 53100 Siena, Italy.
  • Bouajila E; IBMM, CNRS, Univ Montpellier, ENSCM, 34000 Montpellier, France.
  • Piveteau C; Drugs and Molecules for Living System, U1177, Inserm, Université de Lille, Faculté de Pharmacie, 59006 Lille, France.
  • Leroux F; Drugs and Molecules for Living System, U1177, Inserm, Université de Lille, Faculté de Pharmacie, 59006 Lille, France.
  • Deprez-Poulain R; Drugs and Molecules for Living System, U1177, Inserm, Université de Lille, Faculté de Pharmacie, 59006 Lille, France.
  • Deprez B; Drugs and Molecules for Living System, U1177, Inserm, Université de Lille, Faculté de Pharmacie, 59006 Lille, France.
  • Licznar-Fajardo P; HydroSciences Montpellier, UMR5151, Univ Montpellier, CNRS, IRD, CHU Montpellier, 34000 Montpellier, France.
  • Crowder MW; Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056, United States.
  • Cendron L; Laboratory of Structural Biology, Department of Biology, University of Padua, 35121 Padova, Italy.
  • Pozzi C; Dipartimento di Biotecnologie, Chimica e Farmacia, Università di Siena, 53100 Siena, Italy.
  • Mangani S; Dipartimento di Biotecnologie, Chimica e Farmacia, Università di Siena, 53100 Siena, Italy.
  • Docquier JD; Dipartimento di Biotecnologie Mediche, Università di Siena, 53100 Siena, Italy.
  • Hernandez JF; Centre d'Ingénierie des Protéines-InBioS, Université de Liège, B-4000 Liège, Belgium.
  • Gavara L; IBMM, CNRS, Univ Montpellier, ENSCM, 34000 Montpellier, France.
J Med Chem ; 65(24): 16392-16419, 2022 12 22.
Article en En | MEDLINE | ID: mdl-36450011
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Tionas / Inhibidores de beta-Lactamasas Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Francia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Tionas / Inhibidores de beta-Lactamasas Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Francia