Tissue healing changes on wounds in rats after treatment with Hancornia speciosa latex in cream-gel formulation.
Acta Cir Bras
; 37(10): e371001, 2022.
Article
en En
| MEDLINE
| ID: mdl-36542039
ABSTRACT
PURPOSE:
Hancornia speciosa latex has shown pharmacological potential in wound healing processes due to its angiogenic, osteogenic, and anti-inflammatory activities. The aims of this study were to carry out a cream-gel formulation with 5, 10 and 25% of H. speciosa serum latex and to evaluate its potential to stimulate the skin regeneration in rats' wounds.METHODS:
One hundred and twenty rats were divided into five groups neutral control with saline (G1), cream-gel based on H. speciosa latex serum at 5% m/v (G2), cream-gel at 15% m/v (G3), cream-gel at 25% m/v (G4), and cream-gel (G5). The animals were euthanized at three, seven, 14 and 21 days after the injury induction, and some parameters were analyzed wound contraction, necrosis, fibrin, polymorphonuclear and mononuclear infiltrates, fibroblast, angiogenesis, hemorrhage, and collagen.RESULTS:
The therapeutic treatment with cream-gel at 15 and 25% is beneficial in the inflammatory phase of healing processes since it increased the angiogenesis and proliferation of mononuclear infiltrations in wounds. Regarding wound contraction, the treatment with cream-gel (5 and 15%) induced a higher rate of contraction in the proliferative phase. The 15% cream-gel formulation stimulated a greater production of collagen in the injured tissues.CONCLUSIONS:
H. speciosa cream-gel is a low-cost herbal medicine which can aid in tissue repair.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Apocynaceae
/
Látex
Límite:
Animals
Idioma:
En
Revista:
Acta Cir Bras
Año:
2022
Tipo del documento:
Article
País de afiliación:
Brasil