Method for trace determination of N-nitrosamines impurities in metronidazole benzoate using high-performance liquid chromatography coupled with atmospheric-pressure chemical ionization tandem mass spectrometry.

Yin, Mingxing; Hu, Yinuo; Fan, Huajun; Wang, Qiulan; Wang, Mengdie; Wang, Wenqing; Shi, Chunyang

Yin, Mingxing; Hu, Yinuo; Fan, Huajun; Wang, Qiulan; Wang, Mengdie; Wang, Wenqing; Shi, Chunyang.

Afiliación

Yin M; Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
Hu Y; Hubei Hongyuan Pharmaceutical Technology Ltd., Huanggang, P. R. China.
Fan H; ICAS Testing Technology Service (Shanghai) Ltd., Shanghai, P. R. China.
Wang Q; Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
Wang M; Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
Wang W; Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
Shi C; Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.

J Sep Sci ; 46(5): e2200225, 2023 Mar.

Article en En | MEDLINE | ID: mdl-36562102

Asunto(s)

Nitrosaminas; Nitrosaminas/análisis; Cromatografía Líquida de Alta Presión; Metronidazol; Espectrometría de Masas en Tándem/métodos; Bloqueadores del Receptor Tipo 1 de Angiotensina II; Preparaciones Farmacéuticas; Benzoatos/análisis

Palabras clave

N-nitrosamines; genotoxic impurities; high-performance liquid chromatography; metronidazole benzoate; multiple reaction monitoring mode

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Nitrosaminas Idioma: En Revista: J Sep Sci Año: 2023 Tipo del documento: Article