Increased length-dependent activation of human engineered heart tissue after chronic &#945;<sub>1A</sub>-adrenergic agonist treatment: testing a novel heart failure therapy.

Rupert, C; López, J E; Cortez-Toledo, E; De la Cruz Cabrera, O; Chesler, N C; Simpson, P C; Campbell, S G; Baker, A J

Increased length-dependent activation of human engineered heart tissue after chronic α_1A-adrenergic agonist treatment: testing a novel heart failure therapy.

Rupert, C; López, J E; Cortez-Toledo, E; De la Cruz Cabrera, O; Chesler, N C; Simpson, P C; Campbell, S G; Baker, A J.

Afiliación

Rupert C; Propria LLC, Branford, Connecticut, United States.
López JE; Division of Cardiovascular Medicine, Department of Internal Medicine, University of California Davis, Davis, California, United States.
Cortez-Toledo E; Division of Cardiovascular Medicine, Department of Internal Medicine, University of California Davis, Davis, California, United States.
De la Cruz Cabrera O; Kent State University, Kent, Ohio, United States.
Chesler NC; Edwards Lifesciences Foundation Cardiovascular Innovation Research Center, Irvine, California, United States.
Simpson PC; Department of Biomedical Engineering, University of California, Irvine, California, United States.
Campbell SG; Cardiology Division, Veterans Affairs Medical Center, San Francisco, California, United States.
Baker AJ; Department of Medicine, University of California, San Francisco, California, United States.

Am J Physiol Heart Circ Physiol ; 324(3): H293-H304, 2023 03 01.

Article en En | MEDLINE | ID: mdl-36637971

Asunto(s)

Insuficiencia Cardíaca; Células Madre Pluripotentes Inducidas; Humanos; Animales; Porcinos; Agonistas Adrenérgicos/metabolismo; Agonistas Adrenérgicos/farmacología; Agonistas Adrenérgicos/uso terapéutico; Contracción Miocárdica; Células Madre Pluripotentes Inducidas/metabolismo; Insuficiencia Cardíaca/tratamiento farmacológico; Insuficiencia Cardíaca/metabolismo; Miocitos Cardíacos/metabolismo; Receptores Adrenérgicos/metabolismo; Receptores Adrenérgicos/uso terapéutico; Receptores Adrenérgicos alfa 1/metabolismo

Palabras clave

engineered heart tissue; heart failure; human; induced pluripotent stem cell; α1A-adrenergic receptor

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Células Madre Pluripotentes Inducidas / Insuficiencia Cardíaca Límite: Animals / Humans Idioma: En Revista: Am J Physiol Heart Circ Physiol Asunto de la revista: CARDIOLOGIA / FISIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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