Inhibition of PI3K Class IA Kinases Using GDC-0941 Overcomes Cytoprotection of Multiple Myeloma Cells in the Osteoclastic Bone Marrow Microenvironment Enhancing the Efficacy of Current Clinical Therapeutics.

Kikuchi, Hugh; Amofa, Eunice; Mcenery, Maeve; Schey, Steve Arthur; Ramasamy, Karthik; Farzaneh, Farzin; Calle, Yolanda

Kikuchi, Hugh; Amofa, Eunice; Mcenery, Maeve; Schey, Steve Arthur; Ramasamy, Karthik; Farzaneh, Farzin; Calle, Yolanda.

Afiliación

Kikuchi H; Department of Haemato-Oncology, King's College London, London SE5 9NU, UK.
Amofa E; Department of Haemato-Oncology, King's College London, London SE5 9NU, UK.
Mcenery M; Department of Haemato-Oncology, King's College London, London SE5 9NU, UK.
Schey SA; Department of Haemato-Oncology, King's College London, London SE5 9NU, UK.
Ramasamy K; Department of Haematology, Guys Hospital, Guys and St. Thomas' NHS Foundation Trust, London SE5 9RS, UK.
Farzaneh F; Royal Berkshire Hospital, Oxford University Hospitals, Oxford OX3 7LE, UK.
Calle Y; Department of Haemato-Oncology, King's College London, London SE5 9NU, UK.

Cancers (Basel) ; 15(2)2023 Jan 11.

Article en En | MEDLINE | ID: mdl-36672411

Palabras clave

co-culture system; dexamethasone; high throughput screening; myeloma; osteoclasts; resistance; tumour microenvironment

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Texto completo: 1 Bases de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Cancers (Basel) Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido

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