seco-Pregnane Glycosides from Australian Caustic Vine (Cynanchum viminale subsp. australe).
J Nat Prod
; 86(3): 490-497, 2023 03 24.
Article
en En
| MEDLINE
| ID: mdl-36795946
ABSTRACT
Cynanchum viminale subsp. australe, more commonly known as caustic vine, is a leafless succulent that grows in the northern arid zone of Australia. Toxicity toward livestock has been reported for this species, along with use in traditional medicine and its potential anticancer activity. Disclosed herein are novel seco-pregnane aglycones cynavimigenin A (5) and cynaviminoside A (6), together with new pregnane glycosides cynaviminoside B (7) and cynavimigenin B (8). Cynavimigenin B (8) contains an unprecedented 7-oxobicyclo[2.2.1]heptane moiety in the seco-pregnane series, likely arising from a pinacol-type rearrangement. Interestingly, these isolates displayed only limited cytotoxicity in cancer and normal human cell lines, in addition to low activity against acetylcholinesterase and Sarcoptes scabiei bioassays, suggesting that 5-8 are not associated with the reported toxicity of this plant species.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Cáusticos
/
Cynanchum
Límite:
Humans
País/Región como asunto:
Oceania
Idioma:
En
Revista:
J Nat Prod
Año:
2023
Tipo del documento:
Article
País de afiliación:
Australia