Intermolecular Hydroalkoxylation and Hydrocarboxylation of 2-Azadienes with High Efficiency.
J Org Chem
; 88(5): 3277-3281, 2023 Mar 03.
Article
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| MEDLINE
| ID: mdl-36802598
ABSTRACT
Described here is a method for intermolecular hydroalkoxylation and hydrocarboxylation of 2-azadienes through cobalt-catalyzed hydrogen atom transfer and oxidation. This protocol provides a source of 2-azaallyl cation equivalents under mild conditions, is chemoselective in the presence of other CâC double bonds, and requires no excess amount of added alcohol or oxidant. Mechanistic studies suggest that the selectivity arises from lowering the transition state that leads to the highly stabilized 2-azaallyl radical.
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MEDLINE
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En
Revista:
J Org Chem
Año:
2023
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Article
País de afiliación:
Estados Unidos