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Development of top-down cortical propagations in youth.
Pines, Adam; Keller, Arielle S; Larsen, Bart; Bertolero, Maxwell; Ashourvan, Arian; Bassett, Dani S; Cieslak, Matthew; Covitz, Sydney; Fan, Yong; Feczko, Eric; Houghton, Audrey; Rueter, Amanda R; Saggar, Manish; Shafiei, Golia; Tapera, Tinashe M; Vogel, Jacob; Weinstein, Sarah M; Shinohara, Russell T; Williams, Leanne M; Fair, Damien A; Satterthwaite, Theodore D.
Afiliación
  • Pines A; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94304, USA; The Penn Lifespan Informatics and Neuroimaging Center, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Psychiatry, Neurodevelopment & Psychosis Section, University of Pennsylvan
  • Keller AS; The Penn Lifespan Informatics and Neuroimaging Center, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Psychiatry, Neurodevelopment & Psychosis Section, University of Pennsylvania, Philadelphia, PA, USA.
  • Larsen B; The Penn Lifespan Informatics and Neuroimaging Center, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Psychiatry, Neurodevelopment & Psychosis Section, University of Pennsylvania, Philadelphia, PA, USA.
  • Bertolero M; The Penn Lifespan Informatics and Neuroimaging Center, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Psychiatry, Neurodevelopment & Psychosis Section, University of Pennsylvania, Philadelphia, PA, USA.
  • Ashourvan A; Department of Psychology, The University of Kansas, Lawrence, KS 66045, USA.
  • Bassett DS; Department of Psychiatry, Neurodevelopment & Psychosis Section, University of Pennsylvania, Philadelphia, PA, USA; Departments of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA; Department
  • Cieslak M; The Penn Lifespan Informatics and Neuroimaging Center, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Psychiatry, Neurodevelopment & Psychosis Section, University of Pennsylvania, Philadelphia, PA, USA.
  • Covitz S; The Penn Lifespan Informatics and Neuroimaging Center, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Psychiatry, Neurodevelopment & Psychosis Section, University of Pennsylvania, Philadelphia, PA, USA.
  • Fan Y; Department of Radiology, The University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Feczko E; Masonic Institute for the Developing Brain, Institute of Child Development, College of Education and Human Development, Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN 55414, USA.
  • Houghton A; Masonic Institute for the Developing Brain, Institute of Child Development, College of Education and Human Development, Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN 55414, USA.
  • Rueter AR; Masonic Institute for the Developing Brain, Institute of Child Development, College of Education and Human Development, Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN 55414, USA.
  • Saggar M; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94304, USA.
  • Shafiei G; The Penn Lifespan Informatics and Neuroimaging Center, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Psychiatry, Neurodevelopment & Psychosis Section, University of Pennsylvania, Philadelphia, PA, USA.
  • Tapera TM; The Penn Lifespan Informatics and Neuroimaging Center, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Psychiatry, Neurodevelopment & Psychosis Section, University of Pennsylvania, Philadelphia, PA, USA.
  • Vogel J; The Penn Lifespan Informatics and Neuroimaging Center, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Psychiatry, Neurodevelopment & Psychosis Section, University of Pennsylvania, Philadelphia, PA, USA.
  • Weinstein SM; Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Shinohara RT; Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Williams LM; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94304, USA.
  • Fair DA; Masonic Institute for the Developing Brain, Institute of Child Development, College of Education and Human Development, Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN 55414, USA.
  • Satterthwaite TD; The Penn Lifespan Informatics and Neuroimaging Center, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Psychiatry, Neurodevelopment & Psychosis Section, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: sattertt@pennmedicine.upenn.edu.
Neuron ; 111(8): 1316-1330.e5, 2023 04 19.
Article en En | MEDLINE | ID: mdl-36803653
ABSTRACT
Hierarchical processing requires activity propagating between higher- and lower-order cortical areas. However, functional neuroimaging studies have chiefly quantified fluctuations within regions over time rather than propagations occurring over space. Here, we leverage advances in neuroimaging and computer vision to track cortical activity propagations in a large sample of youth (n = 388). We delineate cortical propagations that systematically ascend and descend a cortical hierarchy in all individuals in our developmental cohort, as well as in an independent dataset of densely sampled adults. Further, we demonstrate that top-down, descending hierarchical propagations become more prevalent with greater demands for cognitive control as well as with development in youth. These findings emphasize that hierarchical processing is reflected in the directionality of propagating cortical activity and suggest top-down propagations as a potential mechanism of neurocognitive maturation in youth.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Corteza Cerebral / Desarrollo Infantil / Desarrollo del Adolescente / Neuroimagen Funcional Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2023 Tipo del documento: Article
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Corteza Cerebral / Desarrollo Infantil / Desarrollo del Adolescente / Neuroimagen Funcional Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2023 Tipo del documento: Article