Memory Precursors and Short-Lived Effector T cell Subsets Have Different Sensitivities to TGFß.
Int J Mol Sci
; 24(4)2023 Feb 15.
Article
en En
| MEDLINE
| ID: mdl-36835342
ABSTRACT
After exposure to an antigen, CD8 T cells reach a decision point about their fate to become either short-lived effector cells (SLECs) or memory progenitor effector cells (MPECs). SLECs are specialized in providing an immediate effector function but have a shorter lifespan and lower proliferative capacity compared to MPECs. Upon encountering the cognate antigen during an infection, CD8 T cells rapidly expand and then contract to a level that is maintained for the memory phase after the peak of the response. Studies have shown that the contraction phase is mediated by TGFß and selectively targets SLECs, while sparing MPECs. The aim of this study is to investigate how the CD8 T cell precursor stage determines TGFß sensitivity. Our results demonstrate that MPECs and SLECs have differential responses to TGFß, with SLECs being more sensitive to TGFß than MPECs. This difference in sensitivity is associated with the levels of TGFßRI and RGS3, and the SLEC-related transcriptional activator T-bet binding to the TGFßRI promoter may provide a molecular basis for increased TGFß sensitivity in SLECs.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Subgrupos de Linfocitos T
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Factor de Crecimiento Transformador beta
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Linfocitos T CD8-positivos
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Memoria Inmunológica
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Int J Mol Sci
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos