Type 2 diabetes complications are associated with liver fibrosis independent of hemoglobin A1c.
Ann Hepatol
; 28(3): 101087, 2023.
Article
en En
| MEDLINE
| ID: mdl-36882138
ABSTRACT
INTRODUCTION AND OBJECTIVES:
The association between type 2 diabetes, non-alcoholic fatty liver disease, and liver fibrosis is well established, but it is unknown whether complications of type 2 diabetes influence fibrosis levels. We defined the complications of type 2 diabetes by the presence of diabetic nephropathy, retinopathy, or neuropathy and aimed to evaluate their association with the degree of liver fibrosis measured by the fibrosis-4 (FIB-4) index. MATERIALS ANDMETHODS:
This is a cross-sectional study evaluating the association of type 2 diabetes complications with liver fibrosis. A total of 2389 participants were evaluated from a primary care practice. FIB-4 was evaluated as a continuous and categorical measure using linear and ordinal logistic regression.RESULTS:
Patients with complications were older, had higher hemoglobin A1c, and a higher median FIB-4 score (1.34 vs. 1.12, P<0.001). On adjusted analysis, type 2 diabetes complications were associated with higher fibrosis by continuous FIB-4 score (Beta-coefficient 0.23, 95% confidence interval [CI] 0.004-1.65) and demonstrated increased odds of fibrosis by categorical FIB-4 score (odds ratio [OR] 4.48, 95% CI 1.7-11.8, P=0.003), independent of hemoglobin A1c level.CONCLUSIONS:
The presence of type 2 diabetes complications is associated with the degree of liver fibrosis, independent of hemoglobin A1c level.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Complicaciones de la Diabetes
/
Diabetes Mellitus Tipo 2
/
Enfermedad del Hígado Graso no Alcohólico
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Ann Hepatol
Asunto de la revista:
GASTROENTEROLOGIA
Año:
2023
Tipo del documento:
Article