Whole-genome sequencing of Candida haemulonii species complex from Brazil and the United States: Genetic diversity and antifungal susceptibility.
Med Mycol
; 61(4)2023 Apr 03.
Article
en En
| MEDLINE
| ID: mdl-36931889
Candida haemulonii complex species is worldwide distributed, and this study aimed to evaluate the resistance to antifungal drugs in cases from Brazil and the United States, and also compare their genetic relationships. A total of 50 strains were studied; most of them from Brazil were from cases of bloodstream infections, while the strains from the United States came from cases of wounds and may be associated with diabetic patients. The vast majority of strains were resistant to amphotericin B, one of the most effective drugs, and susceptible to fluconazole. In addition, 50% of C. pseudohaemulonii strains were resistant to echinocandins. The strains from Brazil and the United States had no genetic relationship and formed two distinct groups. In three Brazilian hospitals, strains were clonal, indicating an intra-hospital transmission. Our findings contribute to guiding therapy in bloodstream fungal infections caused by C. haemulonii species and alerting for nosocomial transmission of this yeast complex species.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Candidemia
/
Antifúngicos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
País/Región como asunto:
America do norte
/
America do sul
/
Brasil
Idioma:
En
Revista:
Med Mycol
Asunto de la revista:
MEDICINA VETERINARIA
/
MICROBIOLOGIA
Año:
2023
Tipo del documento:
Article
País de afiliación:
Brasil