Hemophilia A subjects with an intron-22 gene inversion mutation show CD4<sup>+</sup> T-effector responses to multiple epitopes in FVIII.

Gunasekera, Devi; Vir, Pooja; Karim, Ahmad Faisal; Ragni, Margaret V; Pratt, Kathleen P

Hemophilia A subjects with an intron-22 gene inversion mutation show CD4⁺ T-effector responses to multiple epitopes in FVIII.

Gunasekera, Devi; Vir, Pooja; Karim, Ahmad Faisal; Ragni, Margaret V; Pratt, Kathleen P.

Afiliación

Gunasekera D; Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.
Vir P; Henry Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States.
Karim AF; Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.
Ragni MV; Henry Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States.
Pratt KP; Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.

Front Immunol ; 14: 1128641, 2023.

Article en En | MEDLINE | ID: mdl-36936969

Asunto(s)

Hemofilia A; Humanos; Factor VIII; Intrones/genética; Leucocitos Mononucleares; Mutación; Péptidos/genética; Epítopos de Linfocito T/genética; Inversión Cromosómica; Linfocitos T CD4-Positivos; ARN Mensajero/genética; Citocinas/genética

Palabras clave

epitope mapping; factor VIII; hemophilia A; immune tolerance; intron-22 inversion mutation

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Hemofilia A Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Front Immunol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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