CD93 maintains endothelial barrier function by limiting the phosphorylation and turnover of VE-cadherin.

Lugano, Roberta; Vemuri, Kalyani; Barbera, Stefano; Orlandini, Maurizio; Dejana, Elisabetta; Claesson-Welsh, Lena; Dimberg, Anna

Lugano, Roberta; Vemuri, Kalyani; Barbera, Stefano; Orlandini, Maurizio; Dejana, Elisabetta; Claesson-Welsh, Lena; Dimberg, Anna.

Afiliación

Lugano R; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, The Rudbeck Laboratory, 75185, Uppsala, Sweden.
Vemuri K; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, The Rudbeck Laboratory, 75185, Uppsala, Sweden.
Barbera S; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, The Rudbeck Laboratory, 75185, Uppsala, Sweden.
Orlandini M; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A. Moro, 2, 53100, Siena, Italy.
Dejana E; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, The Rudbeck Laboratory, 75185, Uppsala, Sweden.
Claesson-Welsh L; Vascular Biology Unit, FIRC Institute of Molecular Oncology, Milan, 20129, Italy.
Dimberg A; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, The Rudbeck Laboratory, 75185, Uppsala, Sweden.

FASEB J ; 37(4): e22894, 2023 04.

Article en En | MEDLINE | ID: mdl-36961390

Asunto(s)

Cadherinas; Células Endoteliales; Animales; Ratones; Fosforilación; Células Endoteliales/metabolismo; Cadherinas/genética; Cadherinas/metabolismo; Antígenos CD/genética; Antígenos CD/metabolismo; Permeabilidad Capilar/fisiología; Endotelio Vascular/metabolismo; Células Cultivadas; Uniones Adherentes/metabolismo

Palabras clave

CD93; RhoGTPases; VE-cadherin; blood-brain barrier; endothelial junctions; vascular permeability

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Cadherinas / Células Endoteliales Límite: Animals Idioma: En Revista: FASEB J Asunto de la revista: BIOLOGIA / FISIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Suecia

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