Serologic responses to COVID-19 vaccination in children with history of multisystem inflammatory syndrome (MIS-C).
Vaccine
; 41(17): 2743-2748, 2023 04 24.
Article
en En
| MEDLINE
| ID: mdl-36964000
ABSTRACT
Understanding the serological responses to COVID-19 vaccination in children with history of MIS-C could inform vaccination recommendations. We prospectively enrolled seven children hospitalized with MIS-C and measured SARS-CoV-2 binding IgG antibodies to spike protein variants longitudinally pre- and post-Pfizer-BioNTech BNT162b2 primary series COVID-19 vaccination. We found that SARS-CoV-2 variant cross-reactive IgG antibodies variably waned following acute MIS-C, but were significantly boosted with vaccination and maintained for up to 3 months. We then compared post-vaccination binding, pseudovirus neutralizing, and functional antibody-dependent cell-mediated cytotoxicity (ADCC) titers to the reference strain (Wuhan-hu-1) and Omicron variant (B.1.1.529) among previously healthy children (n = 16) and children with history of MIS-C (n = 7) or COVID-19 (n = 8). Despite the breadth of binding antibodies elicited by vaccination in all three groups, pseudovirus neutralizing and ADCC titers were significantly reduced to the Omicron variant.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
COVID-19
/
Vacuna BNT162
Límite:
Child
/
Humans
Idioma:
En
Revista:
Vaccine
Año:
2023
Tipo del documento:
Article