Noninvasive Skin Respiration (CO2) Measurement Based on Quartz-Enhanced Photoacoustic Spectroscopy.
Anal Chem
; 95(14): 6138-6144, 2023 04 11.
Article
en En
| MEDLINE
| ID: mdl-36987565
ABSTRACT
A noninvasive method for disease diagnosis that does not require complex specialized laboratory facilities and chemical reagents is particularly attractive in the current medical environment. Here, we develop a noninvasive skin respiration sensor based on quartz-enhanced photoacoustic spectroscopy (QEPAS) that can monitor the skin elimination rate of carbon dioxide (CO2). A 3.8 mW distributed feedback laser emitting at 2.0 µm is used as an excitation source, and a three-dimensional (3D)-printed acoustic detection module is designed to apply to the skin as a sensor head. The performance of the noninvasive skin respiration sensor is assessed in terms of detection sensitivity, linearity, long-term stability, and water effect. A minimum detection limit of 35 ppb is achieved at the optimal integration time of 670 s. The skin respiration measurements from eight healthy volunteers are recorded, and the real-time results are analyzed.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Dióxido de Carbono
/
Técnicas Fotoacústicas
Límite:
Humans
Idioma:
En
Revista:
Anal Chem
Año:
2023
Tipo del documento:
Article
País de afiliación:
China