Risk Factors for Multisystem Inflammatory Syndrome in Children: A Case-control Investigation.
Pediatr Infect Dis J
; 42(6): e190-e196, 2023 06 01.
Article
en En
| MEDLINE
| ID: mdl-37000922
ABSTRACT
BACKGROUND:
In a 2020 pilot case-control study using medical records, we reported that non-Hispanic Black children were more likely to develop multisystem inflammatory syndrome in children (MIS-C) after adjustment for sociodemographic factors and underlying medical conditions. Using structured interviews, we investigated patient, household, and community factors underlying MIS-C likelihood.METHODS:
MIS-C case patients hospitalized in 2021 across 14 US pediatric hospitals were matched by age and site to outpatient controls testing positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within 3 months of the admission date. Caregiver interviews queried race/ethnicity, medical history, and household and potential community exposures 1 month before MIS-C hospitalization (case-patients) or after SARS-CoV-2 infection (controls). We calculated adjusted odds ratios (aOR) using mixed-effects multivariable logistic regression.RESULTS:
Among 275 case patients and 496 controls, race/ethnicity, social vulnerability and patient or family history of autoimmune/rheumatologic disease were not associated with MIS-C. In previously healthy children, MIS-C was associated with a history of hospitalization for an infection [aOR 4.8; 95% confidence interval (CI) 2.1-11.0]. Household crowding (aOR 1.7; 95% CI 1.2-2.6), large event attendance (aOR 1.7; 95% CI 1.3-2.1), school attendance with limited masking (aOR 2.6; 95% CI 1.1-6.6), public transit use (aOR 1.8; 95% CI 1.4-2.4) and co-resident testing positive for SARS-CoV-2 (aOR 2.2; 95% CI 1.3-3.7) were associated with increased MIS-C likelihood, with risk increasing with the number of these factors.CONCLUSIONS:
From caregiver interviews, we clarify household and community exposures associated with MIS-C; however, we did not confirm prior associations between sociodemographic factors and MIS-C.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
COVID-19
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Qualitative_research
/
Risk_factors_studies
Límite:
Child
/
Humans
Idioma:
En
Revista:
Pediatr Infect Dis J
Asunto de la revista:
DOENCAS TRANSMISSIVEIS
/
PEDIATRIA
Año:
2023
Tipo del documento:
Article
País de afiliación:
Georgia