Designing Smaller, Synthetic, Functional Mimetics of Sulfated Glycosaminoglycans as Allosteric Modulators of Coagulation Factors.

Abdelfadiel, Elsamani I; Gunta, Rama; Villuri, Bharath Kumar; Afosah, Daniel K; Sankaranarayanan, Nehru Viji; Desai, Umesh R

Abdelfadiel, Elsamani I; Gunta, Rama; Villuri, Bharath Kumar; Afosah, Daniel K; Sankaranarayanan, Nehru Viji; Desai, Umesh R.

Afiliación

Abdelfadiel EI; Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, Virginia 23219, United States.
Gunta R; Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, Virginia 23219, United States.
Villuri BK; Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia 23298, United States.
Afosah DK; Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, Virginia 23219, United States.
Sankaranarayanan NV; Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia 23298, United States.
Desai UR; Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, Virginia 23219, United States.

J Med Chem ; 66(7): 4503-4531, 2023 04 13.

Article en En | MEDLINE | ID: mdl-37001055

Asunto(s)

Glicosaminoglicanos; Sulfatos; Glicosaminoglicanos/farmacología; Glicosaminoglicanos/metabolismo; Sulfatos/química; Trombina/metabolismo; Sitios de Unión

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Sulfatos / Glicosaminoglicanos Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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