Invited Commentary: A Step Toward Safer and More Precise Management of Osteoarthritis Pain.
Am J Epidemiol
; 192(9): 1449-1451, 2023 09 01.
Article
en En
| MEDLINE
| ID: mdl-37083976
In this issue of the Journal, Wei et al. (Am J Epidemiol. 2023;192(9):1432-1448); demonstrate the modification of effect of nonselective nonsteroidal antiinflammatory drugs in the setting of aspirin use for the outcome of cardiovascular events. This study is distinctive in its aim to compare 2 similar therapies in the setting of 2 clinical scenarios (aspirin use vs. not) based on some mechanistic rationale. The use of an active comparator design with a prehypothesized evaluation of treatment heterogeneity can provide compelling evidence to support relevant clinical decisions for which clinical trial evidence is not likely or possible.
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Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Osteoartritis
/
Antiinflamatorios no Esteroideos
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Am J Epidemiol
Año:
2023
Tipo del documento:
Article