Acidity promotes the differentiation of immunosuppressive regulatory T cells.
Eur J Immunol
; 53(6): e2350511, 2023 06.
Article
en En
| MEDLINE
| ID: mdl-37097063
ABSTRACT
The metabolic milieu is emerging as a major contributing factor in the maintenance of the immunosuppressive microenvironment within tumors. In particular, the presence of lactic acid produced by highly glycolytic cancer cells is known to suppress antitumor immune cell subsets while promoting immunosuppressive cell populations, such as regulatory T cells (Tregs). Unlike conventional T cells, Tregs have a unique, potent ability to take up lactic acid to fuel both mitochondrial metabolism and gluconeogenesis, thus supporting suppressive function and proliferation. In this issue of the European Journal of Immunology [Eur. J. Immunol. 2023.532250258], Rao et al. uncover a novel mechanism by which lactic acid can support Treg accumulation within tumors in mice. This study shows that lactic acid, through a pH-dependent mechanism rather than lactate itself, promotes TGFß-induced differentiation of Tregs from conventional CD4+ T cells. These findings build on the already multifaceted role of lactic acid in maintaining an immunosuppressive tumor microenvironment.
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Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Linfocitos T Reguladores
/
Neoplasias
Límite:
Animals
Idioma:
En
Revista:
Eur J Immunol
Año:
2023
Tipo del documento:
Article
País de afiliación:
Canadá