An adaptive soft-sensor for advanced real-time monitoring of an antibody-drug conjugation reaction.

Schiemer, Robin; Weggen, Jan Tobias; Schmitt, Katrin Marianne; Hubbuch, Jürgen

Schiemer, Robin; Weggen, Jan Tobias; Schmitt, Katrin Marianne; Hubbuch, Jürgen.

Afiliación

Schiemer R; Institute of Process Engineering in Life Sciences-Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, Baden-Württemberg, Germany.
Weggen JT; Institute of Process Engineering in Life Sciences-Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, Baden-Württemberg, Germany.
Schmitt KM; Institute of Process Engineering in Life Sciences-Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, Baden-Württemberg, Germany.
Hubbuch J; Institute of Process Engineering in Life Sciences-Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, Baden-Württemberg, Germany.

Biotechnol Bioeng ; 120(7): 1914-1928, 2023 07.

Article en En | MEDLINE | ID: mdl-37190793

Asunto(s)

Inmunoconjugados; Inmunoconjugados/química

Palabras clave

Gaussian process regression; antibody-drug conjugate; extended Kalman filter; process analytical technology; reaction monitoring; soft-sensor

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Inmunoconjugados Tipo de estudio: Prognostic_studies Idioma: En Revista: Biotechnol Bioeng Año: 2023 Tipo del documento: Article País de afiliación: Alemania

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