Nicotinamide N-methyltransferase upregulation contributes to palmitate-elicited peroxisome proliferator-activated receptor transactivation in hepatocytes.

Song, Qing; Wang, Jun; Griffiths, Alexandra; Lee, Samuel Man; Iyamu, Iredia D; Huang, Rong; Cordoba-Chacon, Jose; Song, Zhenyuan

Song, Qing; Wang, Jun; Griffiths, Alexandra; Lee, Samuel Man; Iyamu, Iredia D; Huang, Rong; Cordoba-Chacon, Jose; Song, Zhenyuan.

Afiliación

Song Q; Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, United States.
Wang J; Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, United States.
Griffiths A; Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, United States.
Lee SM; Division of Endocrinology/Diabetes & Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States.
Iyamu ID; Department of Medicinal Chemistry and Molecular Pharmacology, Institute for Drug Discovery, Purdue University, West Lafayette, Indiana, United States.
Huang R; Department of Medicinal Chemistry and Molecular Pharmacology, Institute for Drug Discovery, Purdue University, West Lafayette, Indiana, United States.
Cordoba-Chacon J; Division of Endocrinology/Diabetes & Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States.
Song Z; Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, United States.

Am J Physiol Cell Physiol ; 325(1): C29-C41, 2023 07 01.

Article en En | MEDLINE | ID: mdl-37212549

Asunto(s)

Hígado Graso; Palmitatos; Ratones; Animales; Humanos; Palmitatos/toxicidad; Nicotinamida N-Metiltransferasa/genética; Nicotinamida N-Metiltransferasa/metabolismo; Regulación hacia Arriba; NAD/metabolismo; Activación Transcripcional; PPAR gamma/genética; PPAR gamma/metabolismo; Hepatocitos/metabolismo; Niacinamida/metabolismo; Niacinamida/farmacología; Ácidos Grasos/metabolismo

Palabras clave

NAD; NNMT; PPARÎ³; lipotoxicity; palmitate

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Palmitatos / Hígado Graso Límite: Animals / Humans Idioma: En Revista: Am J Physiol Cell Physiol Asunto de la revista: FISIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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