Testicular Rosai-Dorfman disease clonally related to CMML - Case report and literature review.
Pathol Res Pract
; 247: 154548, 2023 Jul.
Article
en En
| MEDLINE
| ID: mdl-37216748
ABSTRACT
BACKGROUND:
Rosai-Dorfman disease (RDD), a rare form of non-Langerhans cell histiocytosis with heterogenous clinical features, arises from precursor cells that give rise to cells of the histiocytic and monocytic lineages. An association with hematological neoplasms has been reported. Testicular RDD is rarely described, with only 9 reported cases in the literature. Genetic data to assess clonal relationships between RDD and other hematological neoplasms remain scarce. We describe an instance of testicular RDD against a background of chronic myelomonocytic leukemia (CMML), with genetic studies in both neoplasms. CASE PRESENTATION A 72-year-old patient with a history of CMML sought evaluation of growing bilateral testicular nodules. Solitary testicular lymphoma was suspected; orchidectomy was performed. The diagnosis of testicular RDD was established morphologically and confirmed immunohistochemically. Molecular analysis of testicular lesions and of archived patient bone marrow revealed the KRAS variant c 0.35 G>A / p.G12D in both, suggesting a clonal relationship.CONCLUSION:
These observations support classifying RDD as a neoplasm that can be clonally related to myeloid neoplasms.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Linfoma no Hodgkin
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Leucemia Mielomonocítica Crónica
/
Histiocitosis Sinusal
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
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Aged
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Humans
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Male
Idioma:
En
Revista:
Pathol Res Pract
Año:
2023
Tipo del documento:
Article
País de afiliación:
Austria