Dissociation protocols used for sarcoma tissues bias the transcriptome observed in single-cell and single-nucleus RNA sequencing.

Truong, Danh D; Lamhamedi-Cherradi, Salah-Eddine; Porter, Robert W; Krishnan, Sandhya; Swaminathan, Jyothishmathi; Gibson, Amber; Lazar, Alexander J; Livingston, J Andrew; Gopalakrishnan, Vidya; Gordon, Nancy; Daw, Najat C; Navin, Nicholas E; Gorlick, Richard; Ludwig, Joseph A

Truong, Danh D; Lamhamedi-Cherradi, Salah-Eddine; Porter, Robert W; Krishnan, Sandhya; Swaminathan, Jyothishmathi; Gibson, Amber; Lazar, Alexander J; Livingston, J Andrew; Gopalakrishnan, Vidya; Gordon, Nancy; Daw, Najat C; Navin, Nicholas E; Gorlick, Richard; Ludwig, Joseph A.

Afiliación

Truong DD; Sarcoma Medical Oncology Department, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Lamhamedi-Cherradi SE; Sarcoma Medical Oncology Department, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Porter RW; Sarcoma Medical Oncology Department, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Krishnan S; Sarcoma Medical Oncology Department, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Swaminathan J; Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Gibson A; Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Lazar AJ; Division of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Livingston JA; Sarcoma Medical Oncology Department, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Gopalakrishnan V; Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Gordon N; Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Daw NC; Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Navin NE; Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Gorlick R; Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Ludwig JA; Sarcoma Medical Oncology Department, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. jaludwig@mdanderson.org.

BMC Cancer ; 23(1): 488, 2023 May 31.

Article en En | MEDLINE | ID: mdl-37254069

Asunto(s)

Sarcoma de Ewing; Sarcoma; Neoplasias de los Tejidos Blandos; Humanos; Transcriptoma; Sarcoma/genética; Sarcoma de Ewing/genética; Sarcoma de Ewing/patología; Análisis de Secuencia de ARN/métodos; RNA-Seq/métodos

Palabras clave

Desmoplastic small round cell tumor; Ewing sarcoma; Osteosarcoma; RNA-seq; Single-cell; scRNA-seq; snRNA-seq

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Sarcoma / Sarcoma de Ewing / Neoplasias de los Tejidos Blandos Límite: Humans Idioma: En Revista: BMC Cancer Asunto de la revista: NEOPLASIAS Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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