Hydrogels to Recapture Extracellular Matrix Cues That Regulate Vascularization.
Arterioscler Thromb Vasc Biol
; 43(8): e291-e302, 2023 08.
Article
en En
| MEDLINE
| ID: mdl-37317849
The ECM (extracellular matrix) is a 3-dimensional network that supports cellular responses and maintains structural tissue integrity in healthy and pathological conditions. The interactions between ECM and cells trigger signaling cascades that lead to phenotypic changes and structural and compositional turnover of the ECM, which in turn regulates vascular cell behavior. Hydrogel biomaterials are a powerful platform for basic and translational studies and clinical applications due to their high swelling capacity and exceptional versatility in compositions and properties. This review highlights recent developments and uses of engineered natural hydrogel platforms that mimic the ECM and present defined biochemical and mechanical cues for vascularization. Specifically, we focus on modulating vascular cell stimulation and cell-ECM/cell-cell interactions in the microvasculature that are the established biomimetic microenvironment.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Neovascularización Fisiológica
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Hidrogeles
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Ingeniería de Tejidos
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Materiales Biomiméticos
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Matriz Extracelular
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Microvasos
Límite:
Animals
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Humans
Idioma:
En
Revista:
Arterioscler Thromb Vasc Biol
Asunto de la revista:
ANGIOLOGIA
Año:
2023
Tipo del documento:
Article