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SUVmax Above 20 in 18F-FDG PET/CT at Initial Diagnostic Workup Associates with Favorable Survival in Patients with Cancer of Unknown Primary.
Zaun, Gregor; Weber, Manuel; Metzenmacher, Martin; Wiesweg, Marcel; Hilser, Thomas; Zaun, Yasmin; Liffers, Sven; Pogorzelski, Michael; Virchow, Isabel; Eberhardt, Wilfried; Theurer, Sarah; Sabbah, Tanja Abu; Reissig, Timm M; Stuschke, Martin; Kürten, Cornelius; Hussain, Timon; Lang, Stephan; Kasper, Stefan; Fendler, Wolfgang P; Herrmann, Ken; Schuler, Martin.
Afiliación
  • Zaun G; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany; gregor.zaun@uk-essen.de.
  • Weber M; Department of Nuclear Medicine, University Hospital Essen, Essen, Germany.
  • Metzenmacher M; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany.
  • Wiesweg M; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany.
  • Hilser T; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany.
  • Zaun Y; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany; gregor.zaun@uk-essen.de.
  • Liffers S; German Cancer Consortium, Partner Site University Hospital Essen, Essen, Germany.
  • Pogorzelski M; Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, Essen, Germany.
  • Virchow I; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany.
  • Eberhardt W; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany.
  • Theurer S; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany.
  • Sabbah TA; Institute of Pathology, West German Cancer Center, University Hospital Essen, Essen, Germany.
  • Reissig TM; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany.
  • Stuschke M; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany.
  • Kürten C; Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, Essen, Germany.
  • Hussain T; Department of Radiation Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany; and.
  • Lang S; Department of Otorhinolaryngology, West German Cancer Center, University Hospital Essen, Essen, Germany.
  • Kasper S; Department of Otorhinolaryngology, West German Cancer Center, University Hospital Essen, Essen, Germany.
  • Fendler WP; Department of Otorhinolaryngology, West German Cancer Center, University Hospital Essen, Essen, Germany.
  • Herrmann K; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany.
  • Schuler M; German Cancer Consortium, Partner Site University Hospital Essen, Essen, Germany.
J Nucl Med ; 64(8): 1191-1194, 2023 08.
Article en En | MEDLINE | ID: mdl-37321823
ABSTRACT
Cancer of unknown primary (CUP) is a heterogeneous entity with a limited prognosis. Novel prognostic markers are needed for patient stratification in prospective clinical trials exploring innovative therapies.

Methods:

In CUP patients treated at the West German Cancer Center Essen, the prognostic value of 18F-FDG PET/CT at the initial diagnostic workup was analyzed by comparing overall survival (OS) in patients who underwent 18F-FDG PET/CT with those who did not.

Results:

Of 154 patients with a CUP diagnosis, 76 underwent 18F-FDG PET/CT at the initial diagnostic workup. The median overall survival (OS) of the full analysis set was 20.0 mo. Within the PET/CT subgroup, an SUVmax above 20 was associated with significantly superior OS (median OS, not reached vs. 32.0 mo; hazard ratio, 0.261; 95% CI, 0.095-0.713; P = 0.009).

Conclusion:

Our retrospective work shows that an SUVmax above 20 on 18F-FDG PET/CT at the initial diagnostic workup is a favorable prognostic factor in patients with CUP. This finding deserves further prospective studies for validation.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias Primarias Desconocidas / Tomografía Computarizada por Tomografía de Emisión de Positrones Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Nucl Med Año: 2023 Tipo del documento: Article
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias Primarias Desconocidas / Tomografía Computarizada por Tomografía de Emisión de Positrones Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Nucl Med Año: 2023 Tipo del documento: Article