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Are pediatricians familiar with hereditary angioedema?
Chong-Neto, Herberto José; Aroni, Bárbara Padilha; Mansour, Eli; Toledo, Eliana; Serpa, Faradiba Sarquis; Arruda, Luisa Karla; Giavina-Bianchi, Pedro; Valle, Solange Oliveira Rodrigues; de Moraes, Caroline Guth de Freitas Batista; Kruk, Tatielly; Chong-Silva, Débora Carla; Solé, Dirceu; Silva, Luciana Rodrigues; Grumach, Anete S; Rosário Filho, Nelson Augusto; Campos, Régis de Albuquerque.
Afiliación
  • Chong-Neto HJ; Division of Allergy and Immunology, Complexo Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, Brazil.
  • Aroni BP; Division of Allergy and Immunology, Complexo Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, Brazil.
  • Mansour E; Clinical Immunology and Allergy, Department of Clinical Medicine, University of Campinas, Campinas, Brazil.
  • Toledo E; Serviço de Alergia e Imunologia Clínica do Departamento de Pediatria e Cirurgia Pediátrica da Faculdade de Medicina de São José do Rio Preto. São José do Rio Preto, Brazil.
  • Serpa FS; Serviço de Asma, Alergia e Imunologia Clínica, Escola Superior de Ciências da Santa Casa de Misericórdia de Vitória, Vitória, Brazil.
  • Arruda LK; Department of Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
  • Giavina-Bianchi P; Clinical Immunology and Allergy Division, Universidade de São Paulo, São Paulo, Brazil.
  • Valle SOR; Departamento de Clínica Médica, Serviço de Imunologia, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
  • de Moraes CGFB; Division of Allergy and Immunology, Complexo Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, Brazil.
  • Kruk T; Division of Allergy and Immunology, Complexo Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, Brazil.
  • Chong-Silva DC; Division of Allergy and Immunology, Complexo Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, Brazil.
  • Solé D; Division of Allergy, Clinical Immunology and Rheumathology, Department of Pediatrics, Federal University of São Paulo, São Paulo, Brazil.
  • Silva LR; Universidade Federal da Bahia, Divisão de Gastroenterologia Pediátrica, Salvador, Brazil.
  • Grumach AS; Clinical Immunology, Centro Universitario FMABC, Santo André, Brazil.
  • Rosário Filho NA; Division of Allergy and Immunology, Complexo Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, Brazil.
  • Campos RA; Faculdade de Medicina da Universidade Federal da Bahia, Departamento de Medicina Interna e Apoio Diagnóstico, Programa de Pós-Graduação em Ciências da Saúde, Salvador, Brazil.
World Allergy Organ J ; 16(6): 100783, 2023 Jun.
Article en En | MEDLINE | ID: mdl-37332526
ABSTRACT

Background:

Hereditary angioedema (HAE) is an autosomal dominant disease characterized by recurrent episodes of subcutaneous or mucosal edema caused by excess bradykinin. The aim of the present study was to assess the knowledge of pediatricians about hereditary angioedema.

Methods:

An online survey with 12 HAE-related and 14 demographics-related questions was e-mailed to all pediatricians who were members of the Brazilian Society of Pediatrics (n = 17 145) once a week during the months of June and July 2021. The electronic questionnaire assessed clinical manifestations, diagnosis, and treatment of hereditary angioedema in children and adolescents.

Results:

Four hundred and fifty-five pediatricians responded to the questionnaire (2.6%), of whom 55 (12.1%) were board certified in Allergy and Immunology (A/I), while 400 (87.9%) were not (N-A/I). Three hundred and sixty-eight (80.9%) were female, 289 (55.7%) were under 50 years of age, 286 (62.9%) graduated from Medical School more than 10 years previously, 83 (18.2%) held an MSc/PhD degree, and 253 (55.6%) were living in the Southeast Region of Brazil. The median number of correct answers to the questions related to HAE among A/I was 7 out of 12 (58.3%), with median ranging from 4.5 to 8 correct answers, while for N-A/I it was 3 (25%), with median ranging from 2.5 to 4 correct answers (p < 0.001).

Conclusion:

Knowledge about HAE among Brazilian pediatricians, whether board certified in Allergy and Immunology or not, was unsatisfactory. HAE is a rare disease, largely unknown among physicians; therefore, increasing awareness may lead to improvement in diagnosis and treatment.
Palabras clave

Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: World Allergy Organ J Año: 2023 Tipo del documento: Article País de afiliación: Brasil

Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: World Allergy Organ J Año: 2023 Tipo del documento: Article País de afiliación: Brasil