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Relationship between serum uric acid levels and the outcome of STN-DBS in Parkinson's disease.
Chang, Bowen; Ni, Chen; Mei, Jiaming; Xiong, Chi; Chen, Peng; Jiang, Manli; Niu, Chaoshi.
Afiliación
  • Chang B; Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, People's Republic of China.
  • Ni C; Anhui Province Key Laboratory of Brain Function and Brain Disease, Hefei, 230001, People's Republic of China.
  • Mei J; Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, People's Republic of China.
  • Xiong C; Anhui Province Key Laboratory of Brain Function and Brain Disease, Hefei, 230001, People's Republic of China.
  • Chen P; Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, People's Republic of China.
  • Jiang M; Anhui Province Key Laboratory of Brain Function and Brain Disease, Hefei, 230001, People's Republic of China.
  • Niu C; Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, People's Republic of China.
Neurol Sci ; 44(11): 3913-3917, 2023 Nov.
Article en En | MEDLINE | ID: mdl-37340228
ABSTRACT

BACKGROUND:

Uric acid is a natural antioxidant and it has been shown that low levels of uric acid may be a risk factor for the development of Parkinson's disease. We aimed to investigate the relationship between uric acid and improvement of motor symptoms in patients with Parkinson's disease after subthalamic nucleus deep brain stimulation.

METHODS:

We analyzed the correlation between serum uric acid levels in 64 patients with Parkinson's disease and the rate of improvement of motor symptoms 2 years after subthalamic nucleus deep brain stimulation.

RESULTS:

A non-linear correlation was observed between uric acid levels and the rate of motor symptom improvement after subthalamic nucleus deep brain stimulation, during both the drug-off and drug-on periods.

CONCLUSIONS:

Uric acid is positively associated with the rate of motor symptom improvement in subthalamic nucleus deep brain stimulation within a certain range.
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Texto completo: 1 Bases de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Neurol Sci Asunto de la revista: NEUROLOGIA Año: 2023 Tipo del documento: Article
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Neurol Sci Asunto de la revista: NEUROLOGIA Año: 2023 Tipo del documento: Article