Potent Dual Inhibitors of Steroid Sulfatase and 17ß-Hydroxysteroid Dehydrogenase Type 1 with a Suitable Pharmacokinetic Profile for <i>In Vivo</i> Proof-of-Principle Studies in an Endometriosis Mouse Model.

Salah, Mohamed; Tahoun, Mariam; Rudzitis-Auth, Jeannette; Stotz, Lisa; van Koppen, Chris J; Laschke, Matthias W; Abdelsamie, Ahmed S; Frotscher, Martin

Potent Dual Inhibitors of Steroid Sulfatase and 17ß-Hydroxysteroid Dehydrogenase Type 1 with a Suitable Pharmacokinetic Profile for In Vivo Proof-of-Principle Studies in an Endometriosis Mouse Model.

Salah, Mohamed; Tahoun, Mariam; Rudzitis-Auth, Jeannette; Stotz, Lisa; van Koppen, Chris J; Laschke, Matthias W; Abdelsamie, Ahmed S; Frotscher, Martin.

Afiliación

Salah M; Department of Pharmacy, Pharmaceutical and Medicinal Chemistry, Saarland University, Campus C23, 66123 Saarbrücken, Germany.
Tahoun M; Department of Pharmaceutical Chemistry, School of Pharmacy, Newgiza University (NGU), Newgiza, km 22 Cairo-Alexandria Desert Road, 12577 Cairo, Egypt.
Rudzitis-Auth J; Department of Pharmacy, Pharmaceutical and Medicinal Chemistry, Saarland University, Campus C23, 66123 Saarbrücken, Germany.
Stotz L; PharmaCenter Bonn, Pharmaceutical Institute, Department of Pharmaceutical and Medicinal Chemistry, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany.
van Koppen CJ; Institute for Clinical and Experimental Surgery, Saarland University, 66421 Homburg, Germany.
Laschke MW; Department of Obstetrics & Gynecology, Saarland University Hospital, 66421 Homburg, Germany.
Abdelsamie AS; ElexoPharm GmbH, Campus A12, 66123 Saarbrücken, Germany.
Frotscher M; Institute for Clinical and Experimental Surgery, Saarland University, 66421 Homburg, Germany.

J Med Chem ; 66(13): 8975-8992, 2023 07 13.

Article en En | MEDLINE | ID: mdl-37369108

Asunto(s)

Endometriosis; Esteril-Sulfatasa; Femenino; Humanos; Ratones; Animales; Inhibidores Enzimáticos/farmacología; Inhibidores Enzimáticos/uso terapéutico; Inhibidores Enzimáticos/metabolismo; Endometriosis/tratamiento farmacológico; Células HEK293; 17-Hidroxiesteroide Deshidrogenasas; Estrógenos/metabolismo

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Esteril-Sulfatasa / Endometriosis Límite: Animals / Female / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Alemania

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