[Mechanical responses on isolated frog neuromuscular preparations in the presence of calcitonin]. / Risposte meccaniche di preparati neuromuscolari isolati di rana in presenza di calcitonina.
Farmaco Sci
; 41(7): 523-9, 1986 Jul.
Article
en It
| MEDLINE
| ID: mdl-3743745
ABSTRACT
Previous observations had shown that, in the isolated rat preparations, calcitonin facilitates the excitement transmission from autonomic nerve-endings to smooth muscle. The present research, was designed to verify whether this facilitation effect could be present in somatic nerve-endings too. For this reason, we used the isolated frog "sciatic nerve-gastrocnemius muscle" preparation where the calcitonin influence on the beginning of a complete tetanic response was studied. The motor nerve-endings were stimulated at different frequencies. It was observed that the added calcitonin and/or an increased [Ca++] medium induced a complete tetanic response also at stimulating frequencies that, in the controls, provoked only a clonic response. Moreover, both the calcitonin and the increased [Ca++] medium frequently induced an increase in the mechanical muscle tension developed. These facilitating effects were reduced or even abolished with inhibition of Ca++-passage through the cell membrane by nifedipine. Therefore, we could hypothesize that the added calcitonin causes increased Ach-release from the somatic nerve-endings and that this action depends on facilitated Ca++-passage through the cell membrane of the nerve-endings and of the muscle fibres too.
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Bases de datos:
MEDLINE
Asunto principal:
Calcitonina
/
Músculo Liso
/
Unión Neuromuscular
Límite:
Animals
Idioma:
It
Revista:
Farmaco Sci
Año:
1986
Tipo del documento:
Article