Low-noise and high-speed trans-impedance amplifier for nanopore sensor.

Fang, Shaoxi; Yin, Bohua; Xie, Wanyi; He, Shixuan; Liang, Liyuan; Tang, Peng; Tian, Rong; Weng, Ting; Yuan, Jiahu; Wang, Deqiang

Fang, Shaoxi; Yin, Bohua; Xie, Wanyi; He, Shixuan; Liang, Liyuan; Tang, Peng; Tian, Rong; Weng, Ting; Yuan, Jiahu; Wang, Deqiang.

Afiliación

Fang S; Chongqing Key Laboratory of Multi-scale Manufacturing Technology, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714, People's Republic of China.
Yin B; Chongqing School, University of Chinese Academy of Sciences, Chongqing 400714, People's Republic of China.
Xie W; Chongqing Key Laboratory of Multi-scale Manufacturing Technology, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714, People's Republic of China.
He S; Changchun University of Science and Technology, Jilin Province, Changchun 130022, People's Republic of China.
Liang L; Chongqing Key Laboratory of Multi-scale Manufacturing Technology, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714, People's Republic of China.
Tang P; Chongqing School, University of Chinese Academy of Sciences, Chongqing 400714, People's Republic of China.
Tian R; Chongqing Key Laboratory of Multi-scale Manufacturing Technology, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714, People's Republic of China.
Weng T; Chongqing School, University of Chinese Academy of Sciences, Chongqing 400714, People's Republic of China.
Yuan J; Chongqing Key Laboratory of Multi-scale Manufacturing Technology, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714, People's Republic of China.
Wang D; Chongqing School, University of Chinese Academy of Sciences, Chongqing 400714, People's Republic of China.

Rev Sci Instrum ; 94(7)2023 Jul 01.

Article en En | MEDLINE | ID: mdl-37439626

ABSTRACT

ABSTRACT

The small current detection circuit is the core component of the accurate detection of the nanopore sensor. In this paper, a compact, low-noise, and high-speed trans-impedance amplifier is built for the nanopore detection system. The amplifier consists of two amplification stages. The first stage performs low-noise trans-impedance amplification by using ADA4530-1, which is a high-performance FET operational amplifier, and a high-ohm feedback resistor of 1 GΩ. The high pass shelf filter in the second stage recovers the higher frequency above the 3 dB cutoff in the first stage to extend the maximum bandwidth up to 50 kHz. The amplifier shows a low noise below sub-2 pA rms when tuned to have a bandwidth of around 5 kHz. It also guarantees a stable frequency response in the nanopore sensor.

Asunto(s)

Nanoporos; Impedancia Eléctrica

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Nanoporos Idioma: En Revista: Rev Sci Instrum Año: 2023 Tipo del documento: Article