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Anti-inflammatory Effect of Polyunsaturated Fatty Acid N-Acylethanolamines Mediated by Macrophage Activity In Vitro and In Vivo.
Egoraeva, Anastasia; Tyrtyshnaia, Anna; Ponomarenko, Arina; Ivashkevich, Darya; Sultanov, Ruslan; Manzhulo, Igor.
Afiliación
  • Egoraeva A; A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, 690041, Vladivostok, Russia.
  • Tyrtyshnaia A; A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, 690041, Vladivostok, Russia.
  • Ponomarenko A; A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, 690041, Vladivostok, Russia.
  • Ivashkevich D; A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, 690041, Vladivostok, Russia.
  • Sultanov R; A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, 690041, Vladivostok, Russia.
  • Manzhulo I; A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, 690041, Vladivostok, Russia. i-manzhulo@bk.ru.
Inflammation ; 46(6): 2306-2319, 2023 Dec.
Article en En | MEDLINE | ID: mdl-37490220
In recent years, there has been increasing interest in studying the anti-inflammatory activity of polyunsaturated fatty acid ethanolamides (N-acylethanolamines, NAE), which are highly active lipid mediators. The results of this study demonstrate that a dietary supplement (DS) of fatty acid-derived NAEs reduces LPS-induced inflammation. The processes of cell proliferation, as well as the dynamics of Iba-1-, CD68-, and CD163-positive macrophage activity within the thymus and spleen were studied. The production of pro-inflammatory cytokines (TNF, IL1ß, IL6, and INFγ), ROS, NO, and nitrites was evaluated in the blood serum, thymus, and LPS-stimulated RAW264.7 mouse macrophages. In vitro and in vivo experiments have shown that DS (1) prevents LPS-induced changes in the morphological structure of the thymus and spleen; (2) levels out changes in cell proliferation; (3) inhibits the activity of Iba-1 and CD68-positive cells; (4) reduces the production of pro-inflammatory cytokines (TNF, IL1ß, IL6, and INFγ), ROS, and CD68; and (5) enhances the activity of CD-163-positive cells. In general, the results of this study demonstrate the complex effect of DS on inflammatory processes in the central and peripheral immune systems.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Lipopolisacáridos / Interleucina-6 Límite: Animals Idioma: En Revista: Inflammation Año: 2023 Tipo del documento: Article País de afiliación: Rusia

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Lipopolisacáridos / Interleucina-6 Límite: Animals Idioma: En Revista: Inflammation Año: 2023 Tipo del documento: Article País de afiliación: Rusia