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Peptide YY: A Paneth cell antimicrobial peptide that maintains Candida gut commensalism.
Pierre, Joseph F; Peters, Brian M; La Torre, Diana; Sidebottom, Ashley M; Tao, Yun; Zhu, Xiaorong; Cham, Candace M; Wang, Ling; Kambal, Amal; Harris, Katharine G; Silva, Julian F; Zaborina, Olga; Alverdy, John C; Herzog, Herbert; Witchley, Jessica; Noble, Suzanne M; Leone, Vanessa A; Chang, Eugene B.
Afiliación
  • Pierre JF; Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Peters BM; Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA.
  • La Torre D; Department of Clinical Pharmacy and Translational Science, University of Tennessee Health Science Center, Memphis, TN, USA.
  • Sidebottom AM; Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Tao Y; Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Zhu X; Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Cham CM; Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Wang L; Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Kambal A; Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Harris KG; Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Silva JF; Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Zaborina O; Department of Biology, Franklin College, Franklin, IN, USA.
  • Alverdy JC; Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Herzog H; Department of Surgery, University of Chicago, Chicago, IL, USA.
  • Witchley J; Department of Surgery, University of Chicago, Chicago, IL, USA.
  • Noble SM; Garvan Institute of Medical Research, Sydney, Australia.
  • Leone VA; Department of Microbiology and Immunology, School of Medicine, University of California San Francisco, San Francisco, CA, USA.
  • Chang EB; Department of Molecular and Cell Biology, Immunology and Molecular Medicine Division, University of California-Berkeley, CA, USA.
Science ; 381(6657): 502-508, 2023 08 04.
Article en En | MEDLINE | ID: mdl-37535745
ABSTRACT
The mammalian gut secretes a family of multifunctional peptides that affect appetite, intestinal secretions, and motility whereas others regulate the microbiota. We have found that peptide YY (PYY1-36), but not endocrine PYY3-36, acts as an antimicrobial peptide (AMP) expressed by gut epithelial paneth cells (PC). PC-PYY is packaged into secretory granules and is secreted into and retained by surface mucus, which optimizes PC-PYY activity. Although PC-PYY shows some antibacterial activity, it displays selective antifungal activity against virulent Candida albicans hyphae-but not the yeast form. PC-PYY is a cationic molecule that interacts with the anionic surfaces of fungal hyphae to cause membrane disruption and transcriptional reprogramming that selects for the yeast phenotype. Hence, PC-PYY is an antifungal AMP that contributes to the maintenance of gut fungal commensalism.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Candida / Células de Paneth / Péptido YY / Péptidos Antimicrobianos / Antifúngicos Límite: Animals / Humans Idioma: En Revista: Science Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Candida / Células de Paneth / Péptido YY / Péptidos Antimicrobianos / Antifúngicos Límite: Animals / Humans Idioma: En Revista: Science Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos