Viral Vector-Induced Ocular Hypertension in Mice.
Methods Mol Biol
; 2708: 77-97, 2023.
Article
en En
| MEDLINE
| ID: mdl-37558962
ABSTRACT
Viral transduction of the mouse trabecular meshwork using a variety of transgenes associated with glaucoma generates an inducible and reproducible method for generating ocular hypertension due to increased aqueous humor outflow resistance of the conventional outflow pathway. Both adenovirus serotype 5 (Ad5) and lentiviruses have selective tropism for the mouse trabecular meshwork with intraocular injections. Accurate intraocular pressures are easily measured using a rebound tonometer, and aqueous humor outflow facilities can be measured in anesthetized live mice.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Glaucoma
/
Hipertensión Ocular
Límite:
Animals
Idioma:
En
Revista:
Methods Mol Biol
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos