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Viral Vector-Induced Ocular Hypertension in Mice.
Millar, J Cameron; Sundaresan, Yogapriya; Zode, Gulab S; Clark, Abbot F.
Afiliación
  • Millar JC; Department of Pharmacology & Neuroscience, North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, TX, USA.
  • Sundaresan Y; Department of Pharmacology & Neuroscience, North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, TX, USA.
  • Zode GS; Department of Ophthalmology, Gaven Herbert Eye Institute, UC Irvine, Irvine, CA, USA.
  • Clark AF; Department of Pharmacology & Neuroscience, North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, TX, USA.
Methods Mol Biol ; 2708: 77-97, 2023.
Article en En | MEDLINE | ID: mdl-37558962
ABSTRACT
Viral transduction of the mouse trabecular meshwork using a variety of transgenes associated with glaucoma generates an inducible and reproducible method for generating ocular hypertension due to increased aqueous humor outflow resistance of the conventional outflow pathway. Both adenovirus serotype 5 (Ad5) and lentiviruses have selective tropism for the mouse trabecular meshwork with intraocular injections. Accurate intraocular pressures are easily measured using a rebound tonometer, and aqueous humor outflow facilities can be measured in anesthetized live mice.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Glaucoma / Hipertensión Ocular Límite: Animals Idioma: En Revista: Methods Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Glaucoma / Hipertensión Ocular Límite: Animals Idioma: En Revista: Methods Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos