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The body mass index increases the genetic risk scores' ability to predict risk of hepatic damage in European adolescents: The HELENA study.
Seral-Cortes, Miguel; Sabroso-Lasa, Sergio; Gonzalez-Gross, Marcela; Quesada-Gonzalez, Carlos; Stehle, Peter; Gottrand, Frederic; Marcos, Ascension; Esperanza-Diaz, Ligia; Manios, Yannis; Androutsos, Odysseas; Widhalm, Kurt; Molnar, Denes; Huybrechts, Inge; Muntaner, Manon; Meirhaeghe, Aline; Salazar-Tortosa, Diego; Ruiz, Jonatan R; Esteban, Luis Mariano; Labayen, Idoia; Moreno, Luis A.
Afiliación
  • Seral-Cortes M; Growth, Exercise, Nutrition and Development (GENUD) Research Group, Faculty of Health Sciences, Instituto Agroalimentario de Aragón (IA2), Instituto de Investigación Sanitaria Aragón (IIS Aragón), Universidad de Zaragoza, Zaragoza, Spain.
  • Sabroso-Lasa S; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
  • Gonzalez-Gross M; Genetic and Molecular Epidemiology Group (GMEG), Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
  • Quesada-Gonzalez C; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
  • Stehle P; ImFine Research Group, Department of Health and Human Performance, Facultad de Ciencias de la Actividad Física y del Deporte-INEF, Universidad Politécnica de Madrid, Madrid, Spain.
  • Gottrand F; Institute of Nutritional and Food Sciences, Nutritional Physiology, University of Bonn, Bonn, Germany.
  • Marcos A; ImFine Research Group, Department of Health and Human Performance, Facultad de Ciencias de la Actividad Física y del Deporte-INEF, Universidad Politécnica de Madrid, Madrid, Spain.
  • Esperanza-Diaz L; Department of Applied Mathematics to Information and Communication Technologies, Universidad Politécnica de Madrid, Madrid, Spain.
  • Manios Y; Institute of Nutritional and Food Sciences, Nutritional Physiology, University of Bonn, Bonn, Germany.
  • Androutsos O; CHU Lille, Inserm U1286 INFINITE, University of Lille, Lille, France.
  • Widhalm K; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
  • Molnar D; Immunonutrition Group, Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN), Spanish National Research Council (CSIC), Madrid, Spain.
  • Huybrechts I; Immunonutrition Group, Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN), Spanish National Research Council (CSIC), Madrid, Spain.
  • Muntaner M; Department of Nutrition and Dietetics, School of Health Science & Education, Harokopio University, Athens, Greece.
  • Meirhaeghe A; Institute of Agri-food and Life Sciences, Hellenic Mediterranean University Research Centre, Heraklion, Greece.
  • Salazar-Tortosa D; Lab of Clinical Nutrition and Dietetics, Department of Nutrition and Dietetics, School of Physical Education, Sport Science and Dietetics, University of Thessaly, Trikala, Greece.
  • Ruiz JR; Division of Clinical Nutrition and Prevention, Department of Paediatrics, Medical University of Vienna, Vienna, Austria.
  • Esteban LM; Austrian Academic Institute for Clinical Nutrition, Vienna, Austria.
  • Labayen I; Department of Pediatrics, Medical School, University of Pécs, Pécs, Hungary.
  • Moreno LA; International Agency for Research on Cancer, World Health Organization, Lyon, France.
Eur J Clin Invest ; 53(12): e14081, 2023 Dec.
Article en En | MEDLINE | ID: mdl-37608495
BACKGROUND: Hepatic disorders are often complex and multifactorial, modulated by genetic and environmental determinants. During the last years, the hepatic disease has been progressively established from early stages in life. The use of genetic risk scores (GRS) to predict the genetic susceptibility to a particular phenotype among youth has gained interest in recent years. Moreover, the alanine aminotransferase (ALT) blood biomarker is often considered as hepatic screening tool, in combination with imaging techniques. The aim of the present study was to develop an ALT-specific GRS to help in the evaluation of hepatic damage risk in European adolescents. METHODS: A total of 972 adolescents (51.3% females), aged 12.5-17.5 years, from the Healthy Lifestyle in Europe by Nutrition in Adolescence study were included in the analyses. The sample incorporated adolescents in all body mass index (BMI) categories and was divided considering healthy/unhealthy ALT levels, using sex-specific cut-off points. From 1212 a priori ALT-related single nucleotide polymorphisms (SNPs) extracted from candidate gene selection, a first screening of 234 SNPs univariately associated was established, selecting seven significant SNPs (p < .05) in the multivariate model. An unweighted GRS (uGRS) was developed by summing the number of reference alleles, and a weighted GRS (wGRS), by multiplying each allele to its estimated coefficient. RESULTS: The uGRS and wGRS were significantly associated with ALT (p < .001). The area under curve was obtained integrating BMI as clinical factor, improving the predictive ability for uGRS (.7039) and wGRS (.7035), using 10-fold internal cross-validation. CONCLUSIONS: Considering BMI status, both GRSs could contribute as complementary tools to help in the early diagnosis of hepatic damage risk in European adolescents.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Adolescent / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Eur J Clin Invest Año: 2023 Tipo del documento: Article País de afiliación: España

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Adolescent / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Eur J Clin Invest Año: 2023 Tipo del documento: Article País de afiliación: España