A measles virus-based vaccine induces robust chikungunya virus-specific CD4<sup>+</sup> T-cell responses in a phase II clinical trial.

Schmitz, Katharina S; Comvalius, Anouskha D; Nieuwkoop, Nella J; Geers, Daryl; Weiskopf, Daniela; Ramsauer, Katrin; Sette, Alessandro; Tschismarov, Roland; de Vries, Rory D; de Swart, Rik L

A measles virus-based vaccine induces robust chikungunya virus-specific CD4⁺ T-cell responses in a phase II clinical trial.

Schmitz, Katharina S; Comvalius, Anouskha D; Nieuwkoop, Nella J; Geers, Daryl; Weiskopf, Daniela; Ramsauer, Katrin; Sette, Alessandro; Tschismarov, Roland; de Vries, Rory D; de Swart, Rik L.

Afiliación

Schmitz KS; Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
Comvalius AD; Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
Nieuwkoop NJ; Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
Geers D; Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
Weiskopf D; Center for Infectious Disease, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Ramsauer K; Themis Bioscience GmbH, Vienna, Austria, a Subsidiary of Merck & Co., Inc., Rahway, NJ, USA.
Sette A; Center for Infectious Disease, La Jolla Institute for Immunology, La Jolla, CA 92037, USA; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA.
Tschismarov R; Themis Bioscience GmbH, Vienna, Austria, a Subsidiary of Merck & Co., Inc., Rahway, NJ, USA.
de Vries RD; Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
de Swart RL; Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands. Electronic address: r.deswart@erasmusmc.nl.

Vaccine ; 41(43): 6495-6504, 2023 10 13.

Article en En | MEDLINE | ID: mdl-37726181

Asunto(s)

Fiebre Chikungunya; Virus Chikungunya; Vacunas Virales; Adulto; Humanos; Anticuerpos Neutralizantes; Anticuerpos Antivirales; Linfocitos T CD4-Positivos; Linfocitos T CD8-positivos; Fiebre Chikungunya/prevención & control; Epítopos de Linfocito T; Vacuna Antisarampión; Virus del Sarampión

Palabras clave

Chikungunya; Measles; T-cells; Vaccination; Vector-based vaccines; Virus

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Vacunas Virales / Virus Chikungunya / Fiebre Chikungunya Tipo de estudio: Clinical_trials Límite: Adult / Humans Idioma: En Revista: Vaccine Año: 2023 Tipo del documento: Article País de afiliación: Países Bajos

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