Reviving immunogenic cell death upon targeting TACC3 enhances T-DM1 response in HER2-positive breast cancer.

Gedik, Mustafa Emre; Saatci, Ozge; Oberholtzer, Nathaniel; Uner, Meral; Akbulut, Ozge; Cetin, Metin; Aras, Mertkaya; Ibis, Kubra; Caliskan, Burcu; Banoglu, Erden; Wiemann, Stefan; Uner, Aysegul; Aksoy, Sercan; Mehrotra, Shikhar; Sahin, Ozgur

Gedik, Mustafa Emre; Saatci, Ozge; Oberholtzer, Nathaniel; Uner, Meral; Akbulut, Ozge; Cetin, Metin; Aras, Mertkaya; Ibis, Kubra; Caliskan, Burcu; Banoglu, Erden; Wiemann, Stefan; Uner, Aysegul; Aksoy, Sercan; Mehrotra, Shikhar; Sahin, Ozgur.

Afiliación

Gedik ME; Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, 29425, USA.
Saatci O; Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, 29425, USA.
Oberholtzer N; Department of Drug Discovery and Biomedical Sciences, University of South Carolina, Columbia, SC, 29208, USA.
Uner M; Department of Surgery, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, 29425, USA.
Akbulut O; Department of Pathology, Faculty of Medicine, Hacettepe University, 06100, Ankara, TURKEY.
Cetin M; Department of Molecular Biology and Genetics, Bilkent University, 06800, Ankara, TURKEY.
Aras M; Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, 29425, USA.
Ibis K; Department of Drug Discovery and Biomedical Sciences, University of South Carolina, Columbia, SC, 29208, USA.
Caliskan B; Department of Drug Discovery and Biomedical Sciences, University of South Carolina, Columbia, SC, 29208, USA.
Banoglu E; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, 06560, Ankara, TURKEY.
Wiemann S; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, 06560, Ankara, TURKEY.
Uner A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, 06560, Ankara, TURKEY.
Aksoy S; Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), INF580, Heidelberg, 69120, Germany.
Mehrotra S; Department of Pathology, Faculty of Medicine, Hacettepe University, 06100, Ankara, TURKEY.
Sahin O; Department of Medical Oncology, Hacettepe University Cancer Institute, 06100, Ankara, TURKEY.

bioRxiv ; 2023 Sep 14.

Article en En | MEDLINE | ID: mdl-37745348

Palabras clave

Immunologic cell death; T-DM1; TACC3; antibody drug conjugate; breast cancer; drug resistance; mitotic arrest

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Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: BioRxiv Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos