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Relative resistance of patient-derived envelope sequences to SERINC5-mediated restriction of HIV-1 infectivity.
Nkuwi, Emmanuel; Judicate, George P; Tan, Toong Seng; Barabona, Godfrey; Toyoda, Mako; Sunguya, Bruno; Kamori, Doreen; Ueno, Takamasa.
Afiliación
  • Nkuwi E; Division of Infection and Immunity, Joint Research Center for Human Retrovirus Infection Kumamoto University , Kumamoto, Japan.
  • Judicate GP; Graduate School of Medical Sciences, Kumamoto University , Kumamoto, Japan.
  • Tan TS; Department of Microbiology and Parasitology, The University of Dodoma , Dodoma, Tanzania.
  • Barabona G; Division of Infection and Immunity, Joint Research Center for Human Retrovirus Infection Kumamoto University , Kumamoto, Japan.
  • Toyoda M; Division of Infection and Immunity, Joint Research Center for Human Retrovirus Infection Kumamoto University , Kumamoto, Japan.
  • Sunguya B; Division of Infection and Immunity, Joint Research Center for Human Retrovirus Infection Kumamoto University , Kumamoto, Japan.
  • Kamori D; Division of Infection and Immunity, Joint Research Center for Human Retrovirus Infection Kumamoto University , Kumamoto, Japan.
  • Ueno T; Collaboration Unit for Infection, Joint Research Center for Human Retrovirus Infection, Kumamoto University , Kumamoto, Japan.
J Virol ; 97(10): e0082323, 2023 10 31.
Article en En | MEDLINE | ID: mdl-37768085
IMPORTANCE: Pathogenesis of HIV-1 is enhanced through several viral-encoded proteins that counteract a range of host restriction molecules. HIV-1 Nef counteracts the cell membrane protein SERINC5 by downregulating it from the cell surface, thereby enhancing virion infectivity. Some subtype B reference Envelope sequences have shown the ability to bypass SERINC5 infectivity restriction independent of Nef. However, it is not clear if and to what extent circulating HIV-1 strains can exhibit resistance to SERINC5 restriction. Using a panel of Envelope sequences isolated from 50 Tanzanians infected with non-B HIV-1 subtypes, we show that the lentiviral reporters pseudotyped with patient-derived Envelopes have reduced sensitivity to SERINC5 and that this sensitivity differed among viral subtypes. Moreover, we found that SERINC5 sensitivity within patient-derived Envelopes can be modulated by separate regions, highlighting the complexity of viral/host interactions.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Infecciones por VIH / VIH-1 / Productos del Gen env del Virus de la Inmunodeficiencia Humana / Interacciones Microbiota-Huesped / Proteínas de la Membrana Límite: Humans País/Región como asunto: Africa Idioma: En Revista: J Virol Año: 2023 Tipo del documento: Article País de afiliación: Japón

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Infecciones por VIH / VIH-1 / Productos del Gen env del Virus de la Inmunodeficiencia Humana / Interacciones Microbiota-Huesped / Proteínas de la Membrana Límite: Humans País/Región como asunto: Africa Idioma: En Revista: J Virol Año: 2023 Tipo del documento: Article País de afiliación: Japón