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Negative DNA supercoiling induces genome-wide Cas9 off-target activity.
Newton, Matthew D; Losito, Marialucrezia; Smith, Quentin M; Parnandi, Nishita; Taylor, Benjamin J; Akcakaya, Pinar; Maresca, Marcello; van Eijk, Patrick; Reed, Simon H; Boulton, Simon J; King, Graeme A; Cuomo, Maria Emanuela; Rueda, David S.
Afiliación
  • Newton MD; Department of Infectious Disease, Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0HS, UK; Single Molecule Imaging, MRC-London Institute of Medical Sciences, Du Cane Road, London W12 0HS, UK; DSB Repair Metabolism Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
  • Losito M; Department of Infectious Disease, Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0HS, UK; Single Molecule Imaging, MRC-London Institute of Medical Sciences, Du Cane Road, London W12 0HS, UK; Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge CB2 0AA, UK.
  • Smith QM; Department of Infectious Disease, Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0HS, UK; Single Molecule Imaging, MRC-London Institute of Medical Sciences, Du Cane Road, London W12 0HS, UK.
  • Parnandi N; DSB Repair Metabolism Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
  • Taylor BJ; Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge CB2 0AA, UK.
  • Akcakaya P; Genome Engineering, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, 43183 Gothenburg, Sweden.
  • Maresca M; Genome Engineering, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, 43183 Gothenburg, Sweden.
  • van Eijk P; Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff CF14 4AW, UK.
  • Reed SH; Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff CF14 4AW, UK.
  • Boulton SJ; DSB Repair Metabolism Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
  • King GA; Institute of Structural and Molecular Biology, University College London, London WC1E 6BT, UK. Electronic address: g.king@ucl.ac.uk.
  • Cuomo ME; Early Oncology, Oncology R&D, AstraZeneca, Cambridge CB2 0AA, UK. Electronic address: emanuela.cuomo@astrazeneca.com.
  • Rueda DS; Department of Infectious Disease, Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0HS, UK; Single Molecule Imaging, MRC-London Institute of Medical Sciences, Du Cane Road, London W12 0HS, UK. Electronic address: david.rueda@imperial.ac.uk.
Mol Cell ; 83(19): 3533-3545.e5, 2023 Oct 05.
Article en En | MEDLINE | ID: mdl-37802026
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Sistemas CRISPR-Cas / Edición Génica Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Sistemas CRISPR-Cas / Edición Génica Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido