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Utility of physiologically based pharmacokinetic modeling to predict inter-antibody variability in monoclonal antibody pharmacokinetics in mice.
Liu, Shufang; Humphreys, Sara C; Cook, Kevin D; Conner, Kip P; Correia, Ana R; Jacobitz, Alex W; Yang, Melissa; Primack, Ronya; Soto, Marcus; Padaki, Rupa; Lubomirski, Mariusz; Smith, Richard; Mock, Marissa; Thomas, Veena A.
Afiliación
  • Liu S; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc, South San Francisco, CA, USA.
  • Humphreys SC; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc, South San Francisco, CA, USA.
  • Cook KD; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc, South San Francisco, CA, USA.
  • Conner KP; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc, South San Francisco, CA, USA.
  • Correia AR; Therapeutic Discovery, Amgen, Thousand Oaks, CA, USA.
  • Jacobitz AW; Process Development, Amgen Inc, Thousand Oaks, CA, USA.
  • Yang M; Therapeutic Discovery, Amgen, Thousand Oaks, CA, USA.
  • Primack R; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc, Thousand Oaks, CA, USA.
  • Soto M; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc, Thousand Oaks, CA, USA.
  • Padaki R; Process Development, Amgen Inc, Thousand Oaks, CA, USA.
  • Lubomirski M; Global Biostatistical Science, Amgen Inc, Thousand Oaks, CA, USA.
  • Smith R; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc, South San Francisco, CA, USA.
  • Mock M; Therapeutic Discovery, Amgen, Thousand Oaks, CA, USA.
  • Thomas VA; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc, South San Francisco, CA, USA.
MAbs ; 15(1): 2263926, 2023.
Article en En | MEDLINE | ID: mdl-37824334
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Modelos Biológicos / Anticuerpos Monoclonales Límite: Animals Idioma: En Revista: MAbs Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Modelos Biológicos / Anticuerpos Monoclonales Límite: Animals Idioma: En Revista: MAbs Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos