Antioxidants restore store-operated Ca<sup>2+</sup> entry in patient-iPSC-derived myotubes with tubular aggregate myopathy-associated Ile484ArgfsX21 STIM1 mutation via upregulation of binding immunoglobulin protein.

Sakai-Takemura, Fusako; Saito, Fumiaki; Nogami, Ken'ichiro; Maruyama, Yusuke; Elhussieny, Ahmed; Matsumura, Kiichiro; Takeda, Shin'ichi; Aoki, Yoshitsugu; Miyagoe-Suzuki, Yuko

Antioxidants restore store-operated Ca²⁺ entry in patient-iPSC-derived myotubes with tubular aggregate myopathy-associated Ile484ArgfsX21 STIM1 mutation via upregulation of binding immunoglobulin protein.

Sakai-Takemura, Fusako; Saito, Fumiaki; Nogami, Ken'ichiro; Maruyama, Yusuke; Elhussieny, Ahmed; Matsumura, Kiichiro; Takeda, Shin'ichi; Aoki, Yoshitsugu; Miyagoe-Suzuki, Yuko.

Afiliación

Sakai-Takemura F; Department of Molecular Therapy National Institute of Neuroscience, National Center of Neurology and Psychiatry Tokyo Japan.
Saito F; Department of Neurology, School of Medicine Teikyo University Tokyo Japan.
Nogami K; Department of Molecular Therapy National Institute of Neuroscience, National Center of Neurology and Psychiatry Tokyo Japan.
Maruyama Y; Department of Neurology, Neurological Institute, Graduate School of Medical Science Kyushu University Fukuoka Japan.
Elhussieny A; Department of Molecular Therapy National Institute of Neuroscience, National Center of Neurology and Psychiatry Tokyo Japan.
Matsumura K; Department of Gene Regulation, Faculty of Pharmaceutical Science Tokyo University of Science Chiba Japan.
Takeda S; Department of Molecular Therapy National Institute of Neuroscience, National Center of Neurology and Psychiatry Tokyo Japan.
Aoki Y; Department of Neurology, Faculty of Medicine Minia University Minia Egypt.
Miyagoe-Suzuki Y; Department of Neurology, School of Medicine Teikyo University Tokyo Japan.

FASEB Bioadv ; 5(11): 453-469, 2023 Nov.

Article en En | MEDLINE | ID: mdl-37936920

Palabras clave

Stromal interaction molecule 1; antioxidants; binding immunoglobulin protein; calcium; calcium releaseactivated calcium channel protein 1 (ORAI1); induced pluripotent stem cells; skeletal muscle; storeoperated Ca2+ entry; tubular aggregate myopathy

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