Evolution of SARS-CoV-2 Spikes shapes their binding affinities to animal ACE2 orthologs.
Microbiol Spectr
; 11(6): e0267623, 2023 Dec 12.
Article
en En
| MEDLINE
| ID: mdl-37943512
ABSTRACT
IMPORTANCE Spike-receptor interaction is a critical determinant for the host range of coronaviruses. In this study, we investigated the SARS-CoV-2 WHU01 strain and five WHO-designated SARS-CoV-2 variants of concern (VOCs), including Alpha, Beta, Gamma, Delta, and the early Omicron variant, for their Spike interactions with ACE2 proteins of 18 animal species. First, the receptor-binding domains (RBDs) of Alpha, Beta, Gamma, and Omicron were found to display progressive gain of affinity to mouse ACE2. More interestingly, these RBDs were also found with progressive loss of affinities to multiple ACE2 orthologs. The Omicron RBD showed decreased or complete loss of affinity to eight tested animal ACE2 orthologs, including that of some livestock animals (horse, donkey, and pig), pet animals (dog and cat), and wild animals (pangolin, American pika, and Rhinolophus sinicus bat). These findings shed light on potential host range shift of SARS-CoV-2 VOCs, especially that of the Omicron variant.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Enfermedades de los Gatos
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Quirópteros
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Enfermedades de los Perros
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Glicoproteína de la Espiga del Coronavirus
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Enzima Convertidora de Angiotensina 2
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SARS-CoV-2
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COVID-19
Límite:
Animals
Idioma:
En
Revista:
Microbiol Spectr
Año:
2023
Tipo del documento:
Article
País de afiliación:
China